Session Information
Date: Monday, June 20, 2016
Session Title: Parkinsonism, MSA, PSP (secondary and parkinsonism-plus)
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: 1) To compare the cognitive and neuropsychological manifestations between the patients with PSP and PD. 2) To find out the severity of caregivers distress of the patients with PSP and PD.
Background: Progressive Supranuclear Palsy (PSP) and Parkinson’s disease (PD) have distinct motor features. But difference in cognitive and behavioral symptoms between the two has been less well studied.
Methods: 25 patients with PSP diagnosed on the basis of National Institute of Neurological Disorder and Stroke-Progressive Supranuclear Palsy (NINDS- PSP) criteria, and 25 patients with PD diagnosed on the basis of UK Parkinson’s disease Society Brain Bank Criteria were assessed on socio demographic and clinical profile. Motor examination was done using Unified Parkinson’s disease Rating Scale (UPDRS) III. Cognitive screening was done using Mini Mental State Examination. Cognitive profile and severity of cognitive impairment was assessed using Mattis Dementia Rating Scale (DRS). Neuropsychiatric Inventory was used to find out the neuropsychological manifestations and the severity of the caregiver’s distress.
Results: According to Mattis DRS, 13 (52%) patients with PSP and 9 (36%) patients with PD had severe cognitive impairment. There was trend of lower mean value on Mattis DRS in patients with PSP as compared to PD in the domain like attention(32.8, 33.88), IP(27.68, 29.24), Construction(3.48,4.72), Conceptualization (29,28.92), Memory (17.88,18.08). Among neuropsychological symptoms hallucination was more frequent in patient with PD (PD- 64%, PSP-16%, p 0.001) whereas, apathy was more common in PSP patients (PSP-68%, PD-44%, p 0.08). According to NPI, aggression was responsible for moderate to severe caregiver distress in 12 PSP patients and 4 PD patients. Similar values for hallucination was 6(PSP) and 5(PD), disinhibition was 6 (PSP) and 5 (PD) whereas, delusion was 3 (PSP) and 7 (PD).
Conclusions: The cognitive and neuropsychological symptoms were worse in patients with PSP as compared to that in PD. Aggression, hallucination, disinhibition and delusion had more bearing on caregiver’s distress.
To cite this abstract in AMA style:
M.U. Kulsum, S.S. Anand, S. Chatterjee, P. Chatterjee, B. Mondal, S. Choudhury, K. Chatterjee, R. Banerjee, S.S. Jha, H. Kumar. Comparison of cognitive and neuropsychological manifestations in patients with progressive supranuclear palsy (Psp) and Parkinson’s disease [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/comparison-of-cognitive-and-neuropsychological-manifestations-in-patients-with-progressive-supranuclear-palsy-psp-and-parkinsons-disease/. Accessed June 15, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/comparison-of-cognitive-and-neuropsychological-manifestations-in-patients-with-progressive-supranuclear-palsy-psp-and-parkinsons-disease/