Session Information
Date: Monday, September 23, 2019
Session Title: Quality of Life
Session Time: 1:45pm-3:15pm
Location: Les Muses Terrace, Level 3
Objective: To compare quality of life (QoL), non-motor symptoms (NMS) burden, autonomy for activities of daily living (ADL) and patient´s principal caregiver status in PD patients with vs patients without “5-2-1 positive criteria” (defined as meeting ≥ 1 of the criteria).
Background: 5- (times oral levodopa tablet intake/day) 2- (hours of OFF time/day) 1 (hour/day of troublesome dyskinesia) criteria have been proposed by a Delphi expert consensus panel for diagnosing advanced Parkinson’s disease (PD)
Method: This is a cross-sectional, observational, monocenter study. Three different instruments were used to assess QoL: the 39-item Parkinson’s disease Quality of Life Questionnaire Summary Index score (PDQ-39SI); a subjective rating of perceived QoL (PQ-10); and the EUROHIS-QOL 8-item index (EUROHIS-QOL8). NMS burden was assessed with the Non-Motor Symptoms scale (NMSS), autonomy for ADL with the Swab&England ADLS score (ADLS), and caregiver burden with the Zarit Caregiver Burden Inventory (ZCBI) and Caregiver Strain Index (CSI).
Results: From a cohort of 102 PD patients (65.4±8.2 years old, 53.9% males; disease duration 4.7±4.5 years), 20 (19.6%) presented positive 5-2-1 criteria: 6.9% for 5, 17.6% for 2, and 4.9% for 1. The 37.5% (12/32) and 25% (5/20) of patients with motor complications and dyskinesia, respectively, presented 5-2-1 negative criteria. Both health-related (PDQ-39SI, 25.6±14 vs 12.1±9.2; p<0.0001) and global QoL (PQ-10, 6.1±2 vs 7.1±1.3; p=0.007; EUROHIS-QOL8, 3.5±0.5 vs 3.7±0.4; p=0.034) was worse in patients with 5-2-1 positive criteria. Non-motor symptoms burden (NMSS total score, 64.8 ± 44.8 vs 39.4 ± 35.1; p<0.0001), autonomy for activities of daily living (ADLS, 73.5 ± 13.1 vs 89.2 ± 9.3; p<0.0001) and patient´s principal caregiver strain (CSI, 4.3 ± 3 vs 1.5 ± 1.6; p<0.0001) and burden (ZCBI, 28.4 ± 12.5 vs 10.9 ± 9.8; p<0.0001) was worse in patients with 5-2-1 positive criteria.
Conclusion: QoL is worse in patients meeting ≥ 1 of the 5-2-1 criteria. This group of patients and their caregivers are as a whole more affected. These criteria could be useful for identifying patients in which it is necessary to optimize Parkinson´s treatment.
References: 1. Antonini A, Odin P, Kleinman L, Skalicky A, Marshall T, Sail K, et al. Implementing a Delphi Panel to Improve Understanding of Patient Characteristics of Advanced Parkinson´s Disease. Mov Disord 2015;30:S1186. 2. Santos-García D, Parra J, Arroyo G, Bergmann L, Catalán MJ. Applying “5-2-1” Diagnosing Criteria for Advanced Parkinson’s Disease to an Observational Study Population Treated with Levodopa-carbidopa Intestinal Gel. E-Poster Presentation (EPR3073). 4TH Congress of the European Academy of Neurology, Lisbon, June 16-19, 2018.
To cite this abstract in AMA style:
D. Santos, T. de Deus, E. Suárez Castro, A. Aneiros. Motor and non-motor symptoms burden, autonomy, quality of life and principal caregiver status is worse in patients with 5-2-1 positive criteria: a simple screening tool for identifying PD patients who need an optimization of Parkinson´s treatment. [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/motor-and-non-motor-symptoms-burden-autonomy-quality-of-life-and-principal-caregiver-status-is-worse-in-patients-with-5-2-1-positive-criteria-a-simple-screening-tool-for-identifying-pd-patients-who/. Accessed June 15, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/motor-and-non-motor-symptoms-burden-autonomy-quality-of-life-and-principal-caregiver-status-is-worse-in-patients-with-5-2-1-positive-criteria-a-simple-screening-tool-for-identifying-pd-patients-who/