Objective: To assess the usefulness of the Personal KinetiGraph (PKG) in characterizing the intensity and timing of motor symptoms in Parkinson´s Disease (PD) patients.

Background: PD’s motor symptoms can be difficult to properly characterize based on patient interviews and in-clinic physical examinations. The PKG® has been shown to objectively measure motor symptoms in PD including the presence and timing of bradykinesia, tremor, dyskinesias, motor fluctuations, and response to medications.

Method: Retrospective study of all PD patients followed at a tertiary academic movement disorders center who were assessed by PKG between December 1, 2016 and October 30, 2018. The chart review recorded among other PKG indication and PKG impact on decision making. PKG indications included patient 1-was unable to give all characteristics of response to individual doses of medication, , 2- did not feel any response to medication individual doses but overall felt better, 3-felt no response at all to medication, or f clinician 4- wanted to verify the accuracy of patient´s reported response to medications or 5- initiated treatment and wanted to objectively assess the response (ie no patient input at the time PKG was ordered).

Results: 170 total PKG sessions corresponding to 103 patients (61 males, average age 68.6) were examined. Average disease duration at PKG recording was 7 years. The indications for PKG sessions were as follows: 45 PKG for indication 1, 26 PKG for indication 2, 17 PKG for indication 3, 73 PKG for indication 4, and 9 PKG for indication 5. Of these indications, 67 PKG results allowed the physician to characterize response when patient was unable to give full answer. 65 PKG results allowed the physician to characterize motor symptoms differently than what the patient reported. 29 PKG results confirmed the patient’s original report. 9 PKG results confirmed partial response to initial treatment requiring escalation in treatment.

Conclusion: In our series, PKG corrected or complemented patient input in 132 cases (77.6%) and confirmed it in 38 (22.4%), underlying the importance of characterizing and verifying patient´s history via a wearable device such as PKG in order to optimize medical management.

References: 1.Griffiths RI, Kotschet K, Arfon S, Xu ZM, Johnson W, Drago J, Evans A, Kempster P, Raghav S, Horne MK. Automated assessment of bradykinesia and dyskinesia in Parkinson’s disease. J Parkinsons Dis. 2012;2(1):47-55. 2.Braybrook M, O’Connor S, Churchward P, Perera T, Farzanehfar P, Horne M. An Ambulatory Tremor Score for Parkinson’s Disease J Parkinsons Dis. 2016 Oct 19;6(4):723-731

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MDS Abstracts - https://www.mdsabstracts.org/abstract/is-the-personal-kinetigraph-useful-in-the-management-of-parkinsons-disease-patients-a-retrospective-study-from-a-tertiary-movement-disorder-center/