Session Information
Date: Wednesday, September 25, 2019
Session Title: Non-Motor Symptoms
Session Time: 1:15pm-2:45pm
Location: Agora 3 West, Level 3
Objective: In this study, we investigated the frequency of non-motor symptoms (NMSs) and their relation with the dominant symptom and the stage of PD.
Background: During the course of the disease, PD patients experience not only motor but also various types of non-motor symptoms. These NMSs affect the quality of life in PD and should be recognized by the clinicians and treated accordingly.
Method: Hundred and eighty patients diagnosed with PD according to United Kingdom Brain Bank criteria were enrolled into the study. The 30-item non-motor symptoms Questionnaire (NMS Quest) was used for evaluating the NMSs. Patients were asked about the presence of NMSs for the last one month. Disease severity was assessed by Modified Hoehn and Yahr scale, the Unified Disease rating scale (UPDRS) was used for the clinical evaluation of PD patients. Patients were divided in two groups according to the dominant symptom as ; 1-Tremor dominant, 2- Akinetic-rigid dominant and according to the H&Y Scale as; 1:Early stages( stage1, 1,5 and 2) ,2:moderate to advanced stages (>stage 2,5).
Results: Patients were mostly men (56.7 %) with the mean age of 64.2±11.5, mean disease duration was 6.22± 5.1years, mean UPDRS scale was 33.1 ±17.4, Hoehn-Yahr scale 1.96± 0.8. The dominant symptom was a tremor in 64.4 % and bradikinesia in 35.6 % of 180 patients. In the whole group, the most common NMSs was nocturia 78.8 %. The 69.8% of the patients had constipation, 57.5% had a depressive mood. The frequency of the type of NMSs in tremor dominant PD was similar to the whole group. But in Akinetic-rigid dominant PD patients orthostatic hypotension 67.2% and restless legs syndrome 64.1% were significantly higher compared to tremor group. Although the most common NMSs was constipation 61.7% in the early stages, the most common NMSs was nocturia 85.9% in moderate to advanced stages. In moderate to advanced stages difficulty of swallowing, dementia, hallucinations and drop attacks were significantly higher compared to early stage.
Conclusion: Although the motor symptoms are well-defined and controlled in PD, the NMSs are frequently underdiagnosed in clinical practice. The type of NMSs may differ according to the dominant symptom and stages of PD.
To cite this abstract in AMA style:
E. Tur, M. Demir, G. Kenangil. The relationship of non-motor symptoms with the dominant symptom and the stage of patients with Parkinson’s disease [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/the-relationship-of-non-motor-symptoms-with-the-dominant-symptom-and-the-stage-of-patients-with-parkinsons-disease/. Accessed May 17, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/the-relationship-of-non-motor-symptoms-with-the-dominant-symptom-and-the-stage-of-patients-with-parkinsons-disease/