Session Information
Date: Monday, June 20, 2016
Session Title: Parkinsonism, MSA, PSP (secondary and parkinsonism-plus)
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To examine the extent of disease progression for multiple system atrophy (MSA) during relatively long duration.
Background: The knowledge of MSA natural history is still insufficient. We previously compared several symptom assessment scales for MSA in 1 year. Then we followed up potential useful scales between 2-3 years, and complemented the information of MSA natural history.
Methods: 21 MSA patients (10 men / 11 women; 17 MSA cerebellar dysfunction subtype [MSA-C] cases / 4 MSA Parkinsonian subtype [MSA-P] cases) were followed up. The Unified MSA Rating Scale (UMSARS), Scales for Scale for Assessment and Rating of Ataxia (SARA) and Barthel index were assessed every one year. Symptom severity was evaluated by score changes and standardized response means (SRMs).
Results: Average score changes and SRMs between 2 years were UMSARS part 1: 8.6 and 0.94, UMSARS part 2: 7.4 and 1.05, UMSARS part 4: 0.8 and 1.19, SARA: 7.0 and 1.17, Barthel index: 17.5 and 0.47. The shorter duration group showed high SRM values in every scales. Analyses of each item revealed high SRM values in hand writing, hygiene, walking, extraocular movement, standing up, postural reflex, standing and speech disturbance.
Conclusions: Shorter duration MSA patients deteriorated faster. Early diagnosis and early care for MSA is important.
To cite this abstract in AMA style:
M. Matsushima, I. Yabe, I. Takahashi, K. Sakushima, F. Nakano, M. Hirotani, T. Kano, K. Horiuchi, H. Houzen, H. Sasaki. The score changes of clinical symptom assessment scales for multiple system atrophy in 2-3 years [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/the-score-changes-of-clinical-symptom-assessment-scales-for-multiple-system-atrophy-in-2-3-years/. Accessed June 14, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/the-score-changes-of-clinical-symptom-assessment-scales-for-multiple-system-atrophy-in-2-3-years/