Category: Huntington's Disease
Objective: To evaluate the cortical excitability difference in Huntington’s disease (HD) and Parkinson’s disease (PD) using paired-pulse transcranial magnetic stimulation (TMS).
Background: TMS is useful to estimate the balance between inhibitory and facilitatory circuits of the primary motor cortex. However, results in HD and PD are inconsistent.
Method: Paired pulse TMS was performed in 9 patients with HD and 2 patients in PD. The clinical profiles of the patients were recorded. All subjects were evaluated short interval intracortical inhibition (SICI) and short interval intracortical facilitation (SICF).
Results: SICI was normal in HD but abnormally reduced in PD. In contrast, SICF was abnormally enhanced in PD, but reduced in HD.
Conclusion: Our results showed that excitability of facilitatory circuits in M1 is reduced in HD. Consistent with previous results, reduction of SICI in PD is presumably due to contamination of enhanced SICF.
To cite this abstract in AMA style:
N. Togashi, M. Hamada, Y. Shirota, T. Toda, K. Nishiyama, K. Hasegwa. Evaluation of Cortical Excitability in Huntington’s Disease and Parkinson’s Disease [abstract]. Mov Disord. 2020; 35 (suppl 1). https://www.mdsabstracts.org/abstract/evaluation-of-cortical-excitability-in-huntingtons-disease-and-parkinsons-disease/. Accessed June 15, 2025.« Back to MDS Virtual Congress 2020
MDS Abstracts - https://www.mdsabstracts.org/abstract/evaluation-of-cortical-excitability-in-huntingtons-disease-and-parkinsons-disease/