Extracellular Small RNAs in Huntington’s disease: from Brain to CSF Analysis
Objective: To investigate a panel of extracellular small non-coding RNAs (sRNAs) in Huntington's disease gene expansion individuals (HDGE) and its potential as CSF biomarkers. Background:…Multi-tracer positron emission tomography reveals early disruption of cerebrospinal fluid clearance in Huntington’s disease
Objective: To evaluate lateral ventricular (LV) positron emission tomography (PET) signal and choroid plexus (CP) volume as biomarkers of disease progression in Huntington’s disease (HD),…Suicidal Ideation and the Hippocampal Histaminergic System in Huntington’s Disease: A PET Study
Objective: To determine whether presence and severity of suicidal ideation (SI) are associated with hippocampal volume and histamine H3 receptor (H3R) PET uptake in people with Huntington’s disease (PwHD). Background: Suicidal ideation occurs in approximately 8–27% of PwHD, yet its causes remain unclear(1–3). The…Intrinsic Suppression of the NRF2–Ferroptosis Defense Axis Defines Selective Vulnerability of D2-Striosome Neurons in Huntington’s Disease
Objective: This study mapped baseline stress-response and cell death programs in healthy human striatal populations to identify intrinsic molecular constraints in D2-striosome neurons and their…Sleep Architecture and Cognitive Performance in Early Huntington’s Disease: A Pilot Study
Objective: Characterize sleep architecture and cognitive performance in people with early Huntington’s disease (HD) and explore their associations. Background: Cognitive impairment is a devastating feature…PET Imaging of Presynaptic Terminals with [18F]SynVesT-1 in Premanifest Huntington’s Disease
Objective: To assess synapse loss in vivo in late premanifest Huntington’s disease (HD) subjects using [18F]SynVesT-1 positron emission tomography (PET). Background: Synaptic damage is believed…Early Reduction in Cerebral Histamine 3 Receptor Expression in People with Huntington’s Disease: Results from the iMarkHD Study
Objective: To quantify histamine 3 receptor (H3R) expression using positron emission tomography (PET) in people with Huntington’s disease (PwHD) across different stages of disease progression.…Correlations of plasma glial fibrillary acidic protein levels with glymphatic system impairment in Huntington’s disease
Objective: To investigate whether plasma glial fibrillary acidic protein (GFAP) levels are related to glymphatic system function in Huntington's disease (HD). Background: Plasma GFAP levels has…Widespread White Matter Changes in Manifest Huntington’s Disease
Objective: To characterize white matter changes in Huntington’s Disease (HD). Background: HD is a genetic neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms. Diffusion Tensor…Adult-Onset Chorea and Psychosis in a 59-Year-Old Man with Elevated Anti-Streptolysin O (aso) Titer
Objective: To review the pathophysiology of neuroimmune disease caused by streptococcal infection using as an example a case of a 59-year-old man with choreiform movements…
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