Objective: To assess adherence to a watch type multi-sensor wearable digital device in patients who joined an observational study for the application of wearable, multi-sensor technology to characterize motor function of Parkinson’s disease patients in Japan (SWJ-001).

Background: Wearable devices can supplement and enhance the information available to the clinician, providing continuous measurement and quantitative data. However, the actual time patients wear the device may affect the accuracy of the data. SWJ-001 is a longitudinal, prospective, observational study using the Study Watch (Verily Life Sciences LLC, CA, USA) to characterize motor function of patients with Parkinson’s disease (PD) using a multi-sensor wearable digital device.

Method: Subjects were recruited on the basis of the diagnosis of PD with at least 5 years of history, current treatment with levodopa, suffering wearing off, and planned clinical need for in-patient hospitalization to monitor motor function with or without adjustment of medication or other treatments for PD. Each subject was trained on the use of the Study Watch and instructed to wear it for up to 23 hours per day for up to 2 months at home before and after hospitalization and at least 5 days during hospitalization. Subjects were asked to mark when they took their levodopa medication by pressing a button on the Study Watch and perform seven simple, standardized motor tasks twice a day at home and a number of times specified in the protocol during the hospital stay. The ware time of the Study Watch was evaluated.

Results: Since the study started in July 2019, as of November 10, 2019, 12 patients have been enrolled. Device wear time for these patients ranged from 8.8-23.0 hours (average 19.8 hours). There was no significant difference in wear time between in hospital and at home use. Averages of each task implementation rate were around 90%, with those in hospital higher than at home.

Conclusion: Adherences to the watch wear-time and to the motor tasks are high both in the hospital and at home. This study may provide valuable information on the character of the motor function of PD patients from sensor data analysis.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/an-observational-study-for-the-application-of-wearable-multi-sensor-technology-to-characterize-motor-function-of-parkinsons-disease-patients-in-japan-swj-001-device-adherence/