Category: Surgical Therapy: Parkinson's Disease
Objective: To evaluate if the body side of motor symptoms onset may predict the short-term motor outcome of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s Disease (PD).
Background: Bilateral STN-DBS represents an effective treatment in PD patients. The definition of predictive factors of postoperative STN-DBS outcomes may allow to improve the selection phase and provide reliable prognostic information to patients. The side of motor symptoms onset may influence disease progression, with a faster motor symptom progression in patients with left side lateralization. Moreover, worse cognitive outcomes after STN-DBS have been described in patients with predominantly left-sided motor symptoms.
Method: This retrospective study included consecutive PD patients treated with bilateral STN-DBS at Grenoble University Hospital from 1993 to 2015. All patients were assessed before (baseline condition) and one year after surgery (follow-up condition). Demographic, clinical and neuroimaging data were collected. Motor disease severity was quantified using the MDS-UPDRS-III score. Primary outcome was measured by the percentage change in the MDS-UPDRS-III score obtained in the “on-stimulation/off-medication” condition one year after surgery compared with the score obtained in the preoperative “off-medication” condition. Predictive factors of short-term motor outcome were evaluated through univariate and multivariate linear regression analysis.
Results: A total of 233 PD patients operated on from 1993 to 2015 were included with a one-year follow-up after surgery (143 males [61.40%]; right body onset: 121 [51.90%]; left body onset: 112 [48.10%]; mean age at surgery: 55.31 [± 8.44] years; mean disease duration: 11.61 [± 3.87] years). Multivariate linear regression analysis showed that body side of motor symptoms onset did not predict the short-term motor outcome in the cohort studied (β= .093, 95% CI= -1.967 to 11.497, p= .164).
Conclusion: In this retrospective study, body side of motor symptoms onset did not significantly influence the short-term motor outcome in a large cohort of PD patients treated with bilateral STN-DBS.
To cite this abstract in AMA style:
F. Cavallieri, F. Bove, A. Castrioto, S. Meoni, E. Schmitt, A. Bichon, A. Kistner, P. Pélissier, E. Lhommée, E. Chevrier, S. Chabardès, E. Seigneuret, V. Fraix, E. Moro. Is motor symptoms asymmetry a possible predictor of short-term motor outcome of bilateral STN-DBS in Parkinson’s disease? [abstract]. Mov Disord. 2022; 37 (suppl 2). https://www.mdsabstracts.org/abstract/is-motor-symptoms-asymmetry-a-possible-predictor-of-short-term-motor-outcome-of-bilateral-stn-dbs-in-parkinsons-disease/. Accessed June 15, 2025.« Back to 2022 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/is-motor-symptoms-asymmetry-a-possible-predictor-of-short-term-motor-outcome-of-bilateral-stn-dbs-in-parkinsons-disease/