Category: Allied Healthcare Professionals
Objective: The objective of this study was to determine the effect of 17 β-estradiol (E2) and progesterone (P4) on the activities of Na+ K+ ATPase, monoamine oxidase (MAO), neurotransmitters levels, glucose transporter (GLUT) expression and neurobehavioral characteristics in naturally menopausal female rats of 3 months (young), 12 months
(adult) and 24 months (old) age groups.
Background: Normal brain aging is associated with progressive cellular and increased vulnerability to neurobiological diseases.
Method: The aged rats (12 and 24 months old) (n= 8 for each group) were given subcutaneous injection of E2 (0.1 μg/g body weight) daily and P4 (2.5
μg/g body weight) was injected on alternate days for one month. For the combined treatment similar concentrations of E2 and P4 were given daily. After
treatment period, cortex, striatum, and hippocampus were isolated for further studies. Biochemical parameters such as pro-inflammatory cytokines, tumor
necrosis factor, tyrosine hydroxylase (p-TH), brain-derived neurotrophic factor (BDNF), neurotransmitters (dopamine, acetylcholine, gamma-aminobutyric
acid (GABA) and glutamate), nitrite levels, antioxidant defense enzymes and 4-hydroxynonenal (HNE) levels were measured in the experimental-treated rat
brain.
Results: The results obtained in the present work revealed that normal aging was associated with significant increases in the activity of MAO, HNE levels,
and a decrease in antioxidant status, Na+ – K+ ATPase activity, expression of (GLUT 1 & GLUT 3), BDNF expression levels, neurobehavioral functions and
modulation of glutamate, dopamine, acetylcholine and GABA levels in rats. There was a significantly increased PPARγ, p-TH expression and depletion TNF-α,
IL-1β in various brain areas compared with the E2, P4 and combined treatment group (E+P). Present data showed that (E+P) group, effectively brought
these changes to near normalcy in aging female rats.
Conclusion: Hence, the combined treatment with E2, and P4 in aging rats has a beneficial effect and therapeutic potential for adjunctive therapy for age
related disorder including Parkinson’s disease.
To cite this abstract in AMA style:
P. Kumar, N. Baquer. Estrogen and progesterone influence membrane functions and glucose transporter expression in synaptosomes of different age groups of naturally menopausal rats [abstract]. Mov Disord. 2023; 38 (suppl 1). https://www.mdsabstracts.org/abstract/estrogen-and-progesterone-influence-membrane-functions-and-glucose-transporter-expression-in-synaptosomes-of-different-age-groups-of-naturally-menopausal-rats/. Accessed May 9, 2025.« Back to 2023 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/estrogen-and-progesterone-influence-membrane-functions-and-glucose-transporter-expression-in-synaptosomes-of-different-age-groups-of-naturally-menopausal-rats/