Category: Parkinson's Disease: Cognitive functions
Objective: To validate and replicate clinical subtypes of Parkinson disease.
Background: We recently identified three distinct clinical subtypes of Parkinson disease: motor (predominant motor with intact cognition and psychiatric function); psychiatric & motor (prominent psychiatric symptoms and moderate motor deficits); cognitive & motor (cognitive and motor deficits). Here, we used an independent cohort to validate and replicate these clinical behavioral subtypes of Parkinson disease.
Method: We tested our original behavioral subtype classification of Parkinson disease with an independent cohort (N = 101) of Parkinson disease participants without dementia and the same comprehensive behavioral evaluations assessing motor, cognitive, and psychiatric function. Next, we combined the original (N = 162) and validation (N=101) datasets to test the classification model with the full combined dataset (N = 263). We also generated ten random split-half samples of the combined dataset to establish the reliability of the behavioral subtype classifications. Latent class analyses were applied to the validation, combined, and split-half samples to determine subtype classification; models were selected based on a combination of model fit indices, substantive meaning, and sufficient number of people per class to allow further statistical analyses.
Results: Latent class analyses revealed three behavioral subtypes in the original, independent validation, and combined data sets: motor; psychiatric & motor; cognitive & motor. The 3-class subtype model was also selected in 13/20 (65%) random split-half replications from the combined dataset.
Conclusion: These results demonstrate the validity and reliability of the Parkinson disease clinical subtypes of motor, psychiatric & motor, and cognitive & motor groups.
To be presented at the World Parkinson Congress meeting in July 2023.
To cite this abstract in AMA style:
C. Lessov-Schlaggar, P. Myers, J. Jackson, B. Maiti, P. Kotzbauer, J. Perlmutter, M. Campbell. Validation and replication of Parkinson disease behavioral subtypes [abstract]. Mov Disord. 2023; 38 (suppl 1). https://www.mdsabstracts.org/abstract/validation-and-replication-of-parkinson-disease-behavioral-subtypes/. Accessed June 15, 2025.« Back to 2023 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/validation-and-replication-of-parkinson-disease-behavioral-subtypes/