Objective: to study the significance of myocardial infarction as a developmental factor in parkinsonism and vascular parkinsonism in Uzbekistyan

Background: The prevalence of Parkinson’s disease with cardiological disorders is very high and averages from 120 to 150 cases per 100,000 population. 10 years after the onset of the disease, 65% of patients become severely disabled

Method: 47 patients with Parkinson’s disease and 40 patients with vascular parkinsonism participated in the study.  Myocardial infarction monitoring in all patients was analyzed by randomized method.  The average age of the first group of patients was 52.4 ± 7.24, the average age of the second group was 60.1 ± 7.4..  Patients with PD were selected in accordance with the international criteria of the British brain bank “Parkinson’s Disease Society Brain Bank”.  To exclude other causes of parkinsonism syndrome, patients underwent CT or MRI of the brain.  In patients with PD, the form of the disease (akinetic-rigid, mixed, or trembling) and the functional stage of the disease (according to the Hoehn-Yahr scale) were assessed.

Results: observation of myocardial infarction in the anamnesis of both groups revealed the presence of myocardial infarction in the anamnesis of 35% p≤0,01 of patients in the first group, and in 22.5% p≤0,01 of patients in the second group.  When the total body fat mass was evaluated in both groups of patients, an increase in total body fat mass was found in 20 ± 4.5% p≤0,05 of patients in the first group, and 25± 6.0% in the second group. The comorbidity of Parkinson’s disease and myocardial infarction was r=0,37 of the correlation coefficient, and r=0,41  p≤0,01 of the correlation coeficent between PD and precipitation disorders

Conclusion: as a conclusion, I can say that both in Parkinson’s disease and in vascular parkinsonism, myocardial infarction is a developing factor.  An increase in the total fat mass in the body leads to an increase in the clinical symptoms of the disease.  Therefore, treatment of additional diseases is important in both diseases.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/the-significance-of-myocardial-infarction-as-a-developmental-factor-in-parkinsonism-and-vascular-parkinsonism/