Category: Huntington's Disease
Objective: To clarify the relationship between the baseline serum lipid traits and the clinical characteristics and disease progression in a well-established cohort of Chinese HD patients.
Background: Abnormal lipid metabolism is involved in the pathogenesis of Huntington’s disease (HD), however, there is still limited evidence regarding the role of serum lipid profiles on the clinical characteristics of patients. Elucidating the interplay between peripheral lipids and the clinical characteristics of HD patients may help identify the role of lipids in HD progression and further reveal potential targets for intervention.
Method: This study recruited 90 adult-onset Chinese HD patients in the analyses. All participants underwent blood lipids tests after fasting and experienced comprehensive clinical assessment at baseline. Furthermore, 61 patients were followed up to assess their longitudinal changes in clinical features. The associations between baseline lipid traits and the clinical manifestations and disease progression were evaluated using multivariate linear regression analyses. Kaplan–Meier survival analysis and Cox regression models were further performed to assess the effect of lipids on the progression to loss-of-function state, defined by total functional capacity (TFC) <3.
Results: Patients with higher triglyceride (TG) levels at baseline exhibited better motor functions, cognitive performances, and functional capacities. Additionally, higher low-density lipoprotein cholesterol (LDL-C) levels were significantly associated with higher TFC scores and composite UHDRS. Compared to the patients with low levels of TG or LDL-C, the annual change of total motor score was significantly slower in patients with intermediate levels of TG or LDL-C. Survival analysis revealed that higher TG levels correlated with a slower progression rate to loss-of-function state.
Conclusion: Baseline lipid traits may provide valuable information on the clinical characteristics of HD patients. Our findings first reported the protective role of TG and LDL-C against the disease progression of HD.
To cite this abstract in AMA style:
SR. Zhang, YF. Cheng, HF. Shang. Baseline lipid traits and the clinical characteristics and disease progression in Huntington’s disease [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/baseline-lipid-traits-and-the-clinical-characteristics-and-disease-progression-in-huntingtons-disease/. Accessed May 18, 2025.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/baseline-lipid-traits-and-the-clinical-characteristics-and-disease-progression-in-huntingtons-disease/