Category: Tremor
Objective: To examine the clinical outcomes and their relationship with patients’ baseline demographic and clinical features and lesion characteristics at 6-month follow-up in ET patients.
Background: Factors predicting clinical outcomes after MR-guided focused ultrasound (MRgFUS)-thalamotomy in patients with essential tremor (ET) are not well known.
Method: 127 patients were prospectively evaluated at 1 (n = 122), 3 (n = 102), and 6 months (n = 78) after MRgFUS-thalamotomy. MRI was obtained at 6 months (n=60). Primary outcomes included: 1) Change in the Clinical Rating Scale of Tremor (CRST)-A+B score in the treated hand. 2) Frequency and severity of adverse events (AEs) at 6 monthsThe primary outcomes included the change in the Clinical Rating Scale of Tremor (CRST)-A+B score in the treated hand and the frequency and severity of adverse events (AEs) at 6 months. Secondary outcomes included changes in all subitems of the CRST scale in the treated hand, CRST-C, axial tremor (face, head, voice, tongue) and , AEs and correlation of primary outcomes with lesion characteristics.. Statistical analysis included linear mixed, standard and logistic regression models.
Results: Scores for CRST-A+B, CRST-A, CRST-B in the treated hand, CRST-C, and axial tremor were improved at each evaluation (p<0.001). Five patients had severe AEs at 1 month that became mild throughout the follow-up. Mild AEs occurred in 71%, 45%, and 34% of patients at 1, 3, and 6 months, respectively. Five patients had severe AEs at 1 month that became mild throughout the follow-up. Patients’ demographic and clinical features were not associated with and primary outcomes. Lesion volume wereas associated with the reduction in the CRST-A (p=0.003) and its overlapping with the Vim nucleus with the reduction in and showed a trend towards statistical association with CRST-A+B (p =0.02) and CRST-B(p= 0.008) reduction respectively (p =0.08) at 6 months.
Conclusion: MRgFUS-thalamotomy safely improves hand and axial tremor in ET patients. Transient and mild AEs are frequent. Lesion volume and location are is associated with tremor reduction.
To cite this abstract in AMA style:
M. Rodriguez-Oroz, AA. Arcadi, LGQ. Gonzalez Quarante, IA. Aviles-Olmos, AMB. Bastidas, AJH. Jimenez Huete, AG. Gorospe, JG. Guridi. MRgFUS thalamotomy for essential tremor: Lesion location and clinical outcomes [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/mrgfus-thalamotomy-for-essential-tremor-lesion-location-and-clinical-outcomes/. Accessed May 9, 2025.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/mrgfus-thalamotomy-for-essential-tremor-lesion-location-and-clinical-outcomes/