Objective: To investigate the usefulness of composite autonomic symptom scale 31 (COMPASS-31) in patients with parkinsonism by comparing COMPASS-31 between PD and MSA patients, and correlation analysis between COMPASS-31 and autonomic function test results.

Background: Even though autonomic dysfunction is regarded to be more common in patients with multiple system atrophy (MSA), autonomic dysfunction is also common and disabling in those with Parkinson’s disease (PD). Despite clinical impact of autonomic dysfunction, there are controversies on the evaluation tools in patients with parkinsonism.

Methods: We enrolled patients with early PD and MSA (disease duration less than 4 yrs), and without other diseases affecting on autonomic function. In all enrolled subjects, COMPASS-31 was performed, and heart rate response to deep breathing, Valsalva test, sympathetic skin reflexd (SSR) and head-up tilt test were checked to evaluate autonomic function. We compared total score and sub-scores of COMPASS-31 between patients with PD and MSA. Additionally, correlation analysis between total and sub-score of CAMPASS-31 and AFT results was done in all enrolled subjects.

Results: Totally 32 subjects were enrolled (18 PD patients and 14 MSA patients) in this study. When we compared COMPASS-31 score between patients with PD and MSA, MSA patients showed higher total score and sub-scores than PD patients in orthostatic intolerance, secretomotor, gastrointestinal domains. In correlation analysis, there was significant correlation between total score and sub-scores of COMPASS-31 (orthostatic intolerance and gastrointestinal domains), and recovery time.

Conclusions: COMPASS-31 can be useful tool for differential diagnosis and evaluation of autonomic function in patients with parkinsonism.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/composite-autonomic-symptom-scale-31-compass-31-is-useful-for-evaluation-of-autonomic-dysfunction-in-patients-with-parkinsonism/