Session Information
Date: Monday, June 20, 2016
Session Title: Parkinsonism, MSA, PSP (secondary and parkinsonism-plus)
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: The aim of our study was to describe how different aspects of daily living and health related quality of life (HRQoL) are impaired by atypical parkinsonisms: multiple systemic atrophy of cerebellar (MSA-C) and Parkinsonian (MSA-P) type and progressive supranuclear palsy (PSP). We also aimed to determine how these aspects change over 12-month follow up.
Background: Multiple System Atrophy and Progressive Supranuclear Palsy belong to a group of disorders called atypical parkinsonisms. Maintenance of good quality of life is the main goal in treatment of these disorders, due to lack of causative treatment and poor response to dopaminergic treatments.
Methods: 50 patients were recruited to the longitudinal study (MSA-C n=17, MSA-P n=15, PSP n=18). All patients were assessed at the baseline using UPDRS, MMSE, EuroQoL and PDQ-39 questionnaires, as well as Parkinson plus symptoms structured interview. 21 patients (MSA-P n=6, MSA-C n=8, PSP n=7) underwent second examination after 12 months.
Results: No significant differences were observed in terms of HRQoL, although general decrease in HRQoL was observed in all domains at follow-up. Patients with PSP had significantly higher score in UPDRS I (MSA-P=2.0±1.6, MSA-C=2.1±2.2, PSP=4.3±1.8, p=0.0026), while patients with MSA-C had greater score in UPDRS II (MSA-P=19.3±7.6, MSA-C=12.6±4.4, PSP=19.4±6.3, p=0.003) and III (MSA-P=43.4±14.5, MSA-C=20.7±9.3, PSP=40.4±13.0, p<0.0001). Mental functions (MSA-P=4.4±3.7, MSA-C=4.1±3.9, PSP=8.7±4.0, p=0.001) and oculomotor disturbances (MSA-P=1.5±2.2, MSA-C=0.5±0.7, PSP=12.9±6.0, p<0.0001) were more prominent among PSP patients. Pyramidal symptoms (MSA-P=6.1±1.9, MSA-C=4.2±1.7, PSP=6.8±2.4, p=0.0048) and cerebellar dysfunction (MSA-P=2.9±4.4, MSA-C=11.1±4.5, PSP=2.1±3.3, p<0.0001) were more common among MSA-C patients.
Conclusions: We conclude that HRQoL is generally deteriorated among patients with atypical parkinsonisms. Motor and non-motor symptoms vary between these disorders. Greater involvement into proper care, also palliative, is crucial for maintaining patients good HRQoL.
To cite this abstract in AMA style:
M. Figura, L. Milanowski, B. Kierdaszuk, A. Bartoszek, P. Janik, Z. Jamrozik. Health-related quality of life of multisystem atrophy and progressive supranuclear palsy patients [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/health-related-quality-of-life-of-multisystem-atrophy-and-progressive-supranuclear-palsy-patients/. Accessed June 14, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/health-related-quality-of-life-of-multisystem-atrophy-and-progressive-supranuclear-palsy-patients/