Objective: This study investigates the neuroprotective potential of ethylenediaminetetraacetic acid (EDTA) in reducing the neurotoxic effects of manganese (Mn), focusing on both motor and non-motor symptoms associated with Mn-induced parkinsonian syndrome.

Background: Manganese, although an essential trace element, can become neurotoxic when accumulated in the body, potentially leading to neurodegenerative and neuroaffective disorders, including parkinsonian syndromes.

Method: We used three groups of male Wistar rats for this study. The first group was injected intraperitoneally with 25 mg/kg of Mn, the second group received 25 mg/kg Mn and 4 mg/kg EDTA, and the control group was administered NaCl. These injections were given daily for 12 weeks. We measured the rats’ weights weekly. Post-exposure, the rats were euthanized, and five brain regions –frontal cortex, prefrontal cortex, hippocampus, striatum, and olfactory bulb – were harvested for biochemical assays. These assays measured levels of nitric oxide (NO), lipid peroxidation (LPO), and catalase activity (CAT).

Results: Rats treated with Mn and EDTA showed a weight trajectory similar to the control group, whereas those injected with only Mn exhibited significant weight loss. Biochemical assays revealed elevated levels of NO, LPO, and CAT in the Mn-only group, indicating severe oxidative stress across the studied brain regions. Conversely, rats receiving both Mn and EDTA displayed markedly lower levels of these oxidative markers, suggesting reduced neurotoxicity.

Conclusion: Mn exposure led to significant oxidative stress, correlating with the development of parkinsonian symptoms in rats. However, the coadministration of EDTA markedly mitigated these effects, highlighting its potential as a neuroprotective agent against Mn toxicity. This underscores the need for further research into EDTA’s therapeutic interventions for managing manganese-induced neurodegeneration.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/neuroprotective-efficacy-of-edta-against-manganese-neurotoxicity-implications-for-modulating-parkinsonian-syndromes/