Category: MSA, PSP, CBS: Clinical Trials
Objective: To evaluate the effectiveness of a telemedicine-based (‘Telenursing’) home healthcare model, coordinated by a Parkinsonism Nurse Specialist (PKNS), in improving the quality of life of individuals with atypical parkinsonism (PKS) and their caregivers.
Background: Individuals with PKS experience complex motor and non-motor symptoms, requiring multidisciplinary care to minimize disability and healthcare burden. A PKNS can enhance care coordination, prevent complications, reduce hospitalizations, and optimize symptom management through structured interventions, improving patients’ quality of life and reducing caregiver strain.
Method: This multicenter, randomized, single-blind, controlled clinical trial assesses the effectiveness of a PKNS-coordinated healthcare model versus standard-of-care (SoC) in patients with multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). A minimum of 164 participants was calculated based on expected changes in PDQ-39 scores over 12 months. Randomization was stratified by sex, diagnosis, and Clinical Frailty Scale (CFS) scores. ClinicalTrials.gov identifier NCT05792332
Results: A total of 165 participants (MSA, 78; PSP, 87) were enrolled, with a balanced sex distribution (M/F: 85/80) and a mean age of 68.3 ± 7.7 years. The overall disease duration was 3.8 ± 2.0 years, with a median Hoehn & Yahr (HY) stage of 3 and mean CFS score of 5.2 ± 1.3, indicating moderate frailty. Baseline PDQ-39 and Zarit Burden Interview (ZBI) scores were 69.1 ± 25.0 and 29.5 ± 15.3, respectively. Participants were evenly distributed between the Telenursing arm (n=82) and the SoC arm (n=83). The groups were comparable in terms of age, disease duration and motor severity (HY stage), CSF, PDQ-39 score and caregiver burden.
Conclusion: Baseline data confirm a high disease burden and moderate frailty in the IMPACT population, emphasizing the need for specialized and continuous care. If successful, this model could represent a cost-effective, scalable solution for the management of neurodegenerative diseases, potentially influencing future clinical guidelines.
The ongoing project PNRR-MR1-2022-12376921 is Funded by the European Union – Next Generation EU – NRRP M6C2 – Investment 2.1 Enhancement and strengthening of biomedical research in the NHS
To cite this abstract in AMA style:
R. Cilia, V. Leta, F. Colucci, A. Suppa, F. Valentino, C. Terranova, C. Leuzzi, J. Cordasco, R. Telese, A. Braccia, G. Gaudiano, A. Elia, A. Zampogna, G. Pinola, M. Patera, G. Belluscio, S. Crivellari, E. Antoniazzi, S. Cascino, A. Giaco, A. Masaracchio, C. Moreschi, M. Catotti, R. Eleopra. Integrated Management of atypical Parkinsonism: A home-based patient-Centered healthcare model using Telenursing. Baseline data from the Multicentre IMPACT study [abstract]. Mov Disord. 2025; 40 (suppl 1). https://www.mdsabstracts.org/abstract/integrated-management-of-atypical-parkinsonism-a-home-based-patient-centered-healthcare-model-using-telenursing-baseline-data-from-the-multicentre-impact-study/. Accessed October 5, 2025.« Back to 2025 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/integrated-management-of-atypical-parkinsonism-a-home-based-patient-centered-healthcare-model-using-telenursing-baseline-data-from-the-multicentre-impact-study/