Session Information
Date: Monday, June 20, 2016
Session Title: Parkinson's disease: Non-motor symptoms
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: The aim of this study was to investigate the relationship between cognitive phenotype and 5-HT2A receptor availability in PD patients with visual hallucinations (VH).
Background: There is growing evidence indicating that the serotonergic system may be involved in cognitive processing and in the development of VH. Studies investigating the relationship between cognitive/behavior phenotype and level of 5-HT2A receptor availability in PD with VH are lacking.
Methods: In total, 19 PD patients (8 PD without VH and 11 PD with VH) and 10 age-matched healthy controls participated and completed the full neuropsychological test battery testing visuospatial, executive, memory/language, and frontal function. PET scan using [18F]setoperone, 5-HT2A antagonist radioligand, was acquired in the PD patients. The parametric binding potential (BP) map of [18F]setoperone were calculated with the simplified reference tissue model using the cerebellum as a reference after the frame-based motion correction in each participants. Group analysis and psychometric correlation analysis were done with BP images and z-transformed cognitive measurements using SPM 8.
Results: We found significant decline of processing speed and visuo-perceptual function in PD with VH compared with age matched controls. Performance levels of these functions were not significantly different from PD without VH. Comparison between PD with, and without, VH disclosed several brain regions with BP differences in [18F]setoperone. PD with VH group appears to be reliant on decreased BP in the right insula, bilateral dorsolateral prefrontal cortex, right orbitofrontal cortex, right middle temporal gyrus and right fusiform gyrus. Subsequent correlation analysis revealed, within the top-down information processing network, a significant positive correlation between Visual Object, Space Perception battery, Facial Recognition Test and the level of BP; within the bottom-up information processing network, the Rey Complex Figure Test score and Judgement of Line Orientation Test score showed a negative correlation with the level of BP.
Conclusions: The changes observed in this study imply a relationship between bottom-up/top-down cognitive information processing and 5-HT2A receptor function in PD patient with VH.
To cite this abstract in AMA style:
S.S. Cho, A.P. Strafella, S. Duff-Canning, M. Zurowski, A.C. Vijverman, V. Bruno, C. de Aquino, M. Criaud, P.M. Rusjan, S. Houle, S.H. Fox. The relationship between the cognitive phenotype and 5-HT2A receptor in PD with visual hallucinations [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/the-relationship-between-the-cognitive-phenotype-and-5-ht2a-receptor-in-pd-with-visual-hallucinations/. Accessed June 14, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/the-relationship-between-the-cognitive-phenotype-and-5-ht2a-receptor-in-pd-with-visual-hallucinations/