Session Information
Date: Monday, June 20, 2016
Session Title: Surgical therapy: Parkinson's disease
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: Evaluate the feasibility to serially assess cognitive performance with a new self-administered web-based test after DBS.
Background: Deep brain stimulation (DBS) has become the treatment of choice in advanced Parkinson’s disease (PD). In these patients cognitive long term follow-up may be crucial for optimal disease management. For this purpose we developed a self-administered computerized test intended for longitudinal cognitive testing – Brain on Track (BoT). It can be performed from a home computer, with all subtests including random elements to minimize learning effects1.
Methods: Inclusion criteria: PD diagnosis > 5 years; DBS surgery; able to understand tests and use computer. Participants were asked to perform in-hospital assessments with BoT before DBS surgery (A1), at hospital discharge (A2), one (A4), three (A6) and six months post-surgery (A7). Remote home-based online assessments were conducted at one week post-discharge (A3), two months (A5) and every three months after A7. All patients underwent UPDRS, MMSE and an extended neuropsychological battery at baseline and 12 months.
Results: Were enrolled 32 participants (Oct/2014-Dec/2015): 70.9% male; age 61yrs (sd=6.9); education 7yrs (sd=5.1); disease duration 12.6yrs (sd=4.8); baseline UPDRS III 29 (sd=12.1); UPDRS IV 7(sd=3.7). From these, 23 have reached the 3 month evaluation timeline. All performed A1 and A2 and 95.7% completed A4 and A6. Remote assessments from home were completed by 74% (A3) and 87% (A5). Cognitive performance in A1 presented a significant association with higher education (r=0.71;p<0.001), lower age (r=0.47;p=0.01) and higher MMSE (r=0.38;p<0.04). BoT testing scores at discharge (A2) and the first remote testing session (A3) one week later from home showed no significant differences (95%CI of difference -2.7 to 2.5, p= 0.92). There were significant correlations between A2-A3 (r=0.52;p<0.03) and A5-A6 (r=0.92;p<0.001).
Conclusions: Patients with advanced stage PD were able to perform self-administered online cognitive testing in-hospital and also remotely from home. Furthermore, testing scores were similar in both contexts. These results are encouraging to further study the use of this strategy during long-term disease management after DBS.
References: 1-Ruano L et al. Development of a self-administered web-based test for longitudinal cognitive assessment. http://nature.com/articles/srep19114
To cite this abstract in AMA style:
L. Fontão, R. Barreto, L. Ruano, A. Sousa, A.I. Martins, A. Costa, A. Aires, C. Sousa, J. Lima, J. Pais, M.J. Rosas, R. Vaz, V.T. Cruz. A cognitive monitoring program for individuals with Parkinson’s disease submitted to deep brain stimulation [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/a-cognitive-monitoring-program-for-individuals-with-parkinsons-disease-submitted-to-deep-brain-stimulation/. Accessed June 14, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/a-cognitive-monitoring-program-for-individuals-with-parkinsons-disease-submitted-to-deep-brain-stimulation/