Session Information
Date: Sunday, October 7, 2018
Session Title: Parkinsonism, MSA, PSP (Secondary and Parkinsonism-Plus)
Session Time: 1:45pm-3:15pm
Location: Hall 3FG
Objective: We analyzed longitudinal change in MRI imaging in PSP from the period before clinical diagnosis. Six patients with clinically diagnosed PSP including 1 case of Richardson’s syndrome (RS), predominant cerebellar ataxia (C) 5 and progressive gait freezing (PGF), 3 cases of predominant parkinsonism (P) and 144 healthy controls (NC).
Background: Previous studies on MRI imaging in patients with progressive supranuclear palsy (PSP) showed atrophy of the midbrain, thalamus and insula, suggesting that distribution of atrophic structures is useful for distinguishing PSP from Parkinson’s disease (PD). There is, however, no study on brain quantitative MRI analysis before the establishment of clinical diagnosis of PSP.
Methods: Voxel-based morphometry (VBM) was repeatedly performed at various clinical stages of PSP to identify the distribution of atrophic structira. A P value than 0.001 ( p<0.001) was considered statistically significant. A longitudinal quantitative analysis of the volume of midbrain, thalamus and insula was performed by the structural MRI analysis software.
Results: In VBM, as compared to NC, atrophy of the thalamus was detected in all cases of PSP. Atrophy of the midbrain was shown in RS, C, and atrophy of the caudate nucleus in all cases except RS. In longitudinal quantitative analysis compared with NC, thalamus was atrophic in all cases. Midbrain was atrophic in RS, C and 2 cases of P, caudate nucleus in RS, P, C and PGF, and 1 case of PSP. Atrophy of insula was seen in RS, C, and all cases of P.
Conclusions: Brain quantitative MRI analysis is useful for the early diagnosis of PSP; we have to pay special attention to atrophy of the thalamus.
References: 1. Shao, N., Yang, J., Li, J. & Shang, H. F. Voxelwise meta-analysis of gray matter anomalies in progressive supranuclear palsy and Parkinson’s disease using anatomic likelihood estimation. Front Hum Neurosci 8, 63, doi:10.3389/fnhum.2014.00063 (2014). 2. Shi, H. C. et al. Gray matter atrophy in progressive supranuclear palsy: meta-analysis of voxel-based morphometry studies. Neurol Sci 34, 1049-1055, doi:10.1007/s10072-013-1406-9 (2013). 3. Yu, F., Barron, D. S., Tantiwongkosi, B. & Fox, P. Patterns of gray matter atrophy in atypical parkinsonism syndromes: a VBM meta-analysis. Brain Behav 5, e00329, doi:10.1002/brb3.329 (2015). 4. Hoglinger, G. U. et al. Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria. Mov Disord 32, 853-864, doi:10.1002/mds.26987 (2017). 5. Kanazawa, M. et al. Early clinical features of patients with progressive supranuclear palsy with predominant cerebellar ataxia. Parkinsonism Relat Disord 19, 1149-1151, doi:10.1016/j.parkreldis.2013.07.019 (2013).
To cite this abstract in AMA style:
K. Seo, T. Yamamoto, H. Kawasaki, A. Miyake, T. Hukuoka, Y. Nakazato, T. Takahasi, I. Matunari, H. Matuda, N. Tamura, N. Araki. A longitudinal study of brain quantitative MRI analysis before and after diagnosis of progressive supranuclear palsy [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/a-longitudinal-study-of-brain-quantitative-mri-analysis-before-and-after-diagnosis-of-progressive-supranuclear-palsy/. Accessed June 14, 2025.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/a-longitudinal-study-of-brain-quantitative-mri-analysis-before-and-after-diagnosis-of-progressive-supranuclear-palsy/