Date: Sunday, October 7, 2018
Session Title: Parkinsonism, MSA, PSP (Secondary and Parkinsonism-Plus)
Session Time: 1:45pm-3:15pm
Location: Hall 3FG
Objective: To evaluate the accuracy of the IPD-MDS-PSP criteria to differentiate PSP-Richardson (PSP-R) from PSP-parkinsonism (PSP-P), the most common PSP phenotypes.
Background: The new International Parkinson disease and Movement Disorder Society (IPD-MDS) diagnostic criteria for progressive supranuclear palsy (PSP) was recently delineated to allow an early diagnosis of the various PSP phenotypes.
Methods: Detailed data from 283 out of 350 PSP patients who participated in the ENGENE-PSP case-control study was used to assess the accuracy of the new IPD-MDS-PSP criteria in differentiating PSP-R and PSP-P. The gold standard to define PSP-Richardson was based on the National Institute of Neurological Disorders and Stroke and Society for PSP (NINDS-SPSP) criteria and PSP-Parkinsonism was based on the Williams’ criteria.
Results: The IPD-MDS-PSP criteria failed to distinguish the PSP-R and PSP-P phenotypes. 94.2% (245 out of 260) PSP-R patients meeting the NINDS-SPSP and 54.5% (12 out of 23) PSP-P patients meeting the Williams’ criteria fulfilled both, the IPD-MDS PSP-R and PSP-P criteria. The specificity of the IPD-MDS PSP-R criteria was 47.83% (26.82-69.41%) and of the IPD-MDS PSP-P criteria was 5.77% (3.26-9.34%). The addition of a timeline may improve the diagnostic accuracy.
Conclusions: The recently published IPD-MDS PSP-R and PSP-P criteria are unable to differentiate these phenotypes and need to be revised. We propose possible modifications.
To cite this abstract in AMA style:A. Shoeibi, I. Litvan, J. Juncos, Y. Bordelon, D. Riley, S. Reich, D. Shprecher, D. Hall, C. Marras, B. Kluger, N. Olfati, J. Jankovic. Accuracy of the International Parkinson Disease and Movement Disorder Society Progressive Supranuclear Palsy Diagnostic Criteria (IPD-MDS-PSP) [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/accuracy-of-the-international-parkinson-disease-and-movement-disorder-society-progressive-supranuclear-palsy-diagnostic-criteria-ipd-mds-psp/. Accessed December 5, 2023.
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