MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

MENU 
  • Home
  • Meetings Archive
    • 2024 International Congress
    • 2023 International Congress
    • 2022 International Congress
    • MDS Virtual Congress 2021
    • MDS Virtual Congress 2020
    • 2019 International Congress
    • 2018 International Congress
    • 2017 International Congress
    • 2016 International Congress
  • Keyword Index
  • Resources
  • Advanced Search

Asymmetric olfactory deficit in H&Y stage-1 early onset Parkinson’s disease

J. Wang, R. Stanford, L. Spreen, T. Subramanian, Q. Yang (Hershey, PA, USA)

Meeting: 2018 International Congress

Abstract Number: 1547

Keywords: Olfactory dysfunction

Session Information

Date: Monday, October 8, 2018

Session Title: Parkinson's Disease: Non-Motor Symptoms

Session Time: 1:15pm-2:45pm

Location: Hall 3FG

Objective: To determine if the olfactory deficit in the early-stage Parkinson’s disease (PD) is asymmetric between the two hemispheres ipsilateral and contralateral to the onset body side of PD symptoms in Hoehn & Yahr (H&Y) stage-1 early onset PD patients.

Background: Olfactory dysfunction is prevalent in PD, with deficits in odor detection, identification, and discrimination. The central olfactory system is highly affected by PD pathology. Lewy body deposition, initiates in the olfactory bulb and anterior olfactory nucleus. To date, the cause of olfactory deficits in PD is still not clear. The clinical motor symptoms are always asymmetric at the diagnosis of stage-1 early onset PD. We hypothesize that there is hemispheric asymmetry in olfactory deficits in the patients at this stage.

Methods: The smell identification ability of ten cognitive normal H&Y stage-1 idiopathic PD patients (age 53.8 ± 5.9 years, 4 males, MoCA score 29.4 ± 0.5, 4 subjects with motor symptoms on the right body side) and ten age/sex-matched healthy control subjects (HC) were evaluated using the 40-item University of Pennsylvania Smell Identification Test (UPSIT). Each nostril was tested with 20 items when the other side was air-tight sealed with tape.

Results: There was significant impairment of smell identification function in stage-1 PD compared to the HCs (two-sample t-test, left nostril p = 0.0017; right nostril p = 0.0006). There was no significant difference in UPSIT scores between the left and right nostrils in either PD and HC group (paired t-test, PD p = 0.496; HC p = 0.56). Compared to the nostril ipsilateral to the body side with hemiparkinsonism, the functional deficit in smell identification was significantly worse in the other nostril (paired t-test, p = 0.045).

Conclusions: These preliminary data support the hypothesis of asymmetric functional deficit in olfaction between the hemispheres ipsilateral and contralateral to the onset body side of PD symptoms in stage-1 PD.

To cite this abstract in AMA style:

J. Wang, R. Stanford, L. Spreen, T. Subramanian, Q. Yang. Asymmetric olfactory deficit in H&Y stage-1 early onset Parkinson’s disease [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/asymmetric-olfactory-deficit-in-hy-stage-1-early-onset-parkinsons-disease/. Accessed May 20, 2025.
  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2018 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/asymmetric-olfactory-deficit-in-hy-stage-1-early-onset-parkinsons-disease/

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Safety and Tolerability of a Ketone Supplement in Parkinson's Disease
  • Successful external defibrillation in a patient with bilateral deep brain stimulation
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • What is the appropriate sleep position for Parkinson's disease patients with orthostatic hypotension in the morning?
  • The hardest symptoms that bother patients with Parkinson's disease
  • An Apparent Cluster of Parkinson's Disease (PD) in a Golf Community
  • Life expectancy with and without Parkinson’s disease in the general population
    • Help & Support
    • About Us
    • Cookies & Privacy
    • Wiley Job Network
    • Terms & Conditions
    • Advertisers & Agents
    Copyright © 2025 International Parkinson and Movement Disorder Society. All Rights Reserved.
    Wiley