Session Information
Date: Monday, September 23, 2019
Session Title: Restless Leg Syndrome, RBD and Other Sleep Disorders
Session Time: 1:45pm-3:15pm
Location: Les Muses Terrace, Level 3
Objective: Sleep dysfunction in Parkinson’s disease (PD) is a commonly reported symptom.
Background: Analysis of brain wave synchronicity may help to unravel this phenomenon and serve to support a diagnosis of Parkinson’s disease.
Method: We analyzed EEG output signals from different physiological systems that are synchronously and continuously recorded during night-time sleep (polysomnographic recordings) from 97 healthy subjects (51 female, 46 male, ages 50-95 years) and 40 Parkinson’s disease patients (11 female, 29 male) Time Delay Stability (TDS) method represents the degree of coupling between different frequency bands across brain locations as evaluated via EEG. Segments of brain EEG power are evaluated at defined time windows. Coordinated bursts lead to pronounced cross-correlation within each time window. A time lag can occur between the two signals in physiological coupling, this is defined as time delay stability (TDS). The fraction of time when TDS is observed in the EEG recording, quantifies the degree of coupling strength. Longer periods of TDS reflect stronger coupling.
Results: Parkinson’s patients show much stronger and denser interaction comparing to healthy subjects. There are stronger and denser network interactions during wake and light sleep (LS), weaker and sparser network interactions during REM and deep sleep (DS) (with MW tests p ≤ 0.014, except in the PD group, comparing the link number between wake vs REM p = 0.169, and between LS vs DS p = 0.056) Brain-waves interaction networks for Parkinson’s patients show significantly higher link number and links strength compared to healthy subjects (with MW tests p ≤ 0.012, except in LS p ≈ 0.07).
Conclusion: In patients with Parkinson’s Disease there is a disturbance in the basic physiologic regulation and stratification of signaling during sleep with more synchronicity compared to normal subjects.
To cite this abstract in AMA style:
A. Hohler, O. Vaou, X. Zhang, J. Wang, A. Quaicoe, F. Lombardi, R. Endelapour, J. Holsapple, P. Ivanov. Augmented Brain Wave Synchronicity in Sleep in Parkinson’s Disease Patients [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/augmented-brain-wave-synchronicity-in-sleep-in-parkinsons-disease-patients/. Accessed June 14, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/augmented-brain-wave-synchronicity-in-sleep-in-parkinsons-disease-patients/