Category: Parkinson's Disease: Neurophysiology
Objective: To investigate the temporal and spatial relationship between local field potential (LFP) changes and dyskinesia development.
Background: Levodopa-induced dyskinesias (LID) are an important burden for Parkinson’s disease (PD) patients. However, the underlying pathophysiology remains incompletely understood.
Method: We conducted a prospective, observational study analyzing the correlation between STN/GPi LFPs and the development of LID. Consecutive PD patients with troublesome LID who were subjected to DBS surgery were included. During surgery, bilateral LFPs, EMG and accelerometric signals were simultaneously recorded at baseline for 200 seconds after which subcutaneous apomorphine was injected. The recording continued until 200 seconds after the initiation of dyskinesias. Power spectral analysis was performed. The variation in power was analyzed through time and compared against the distance between the contact position and the sweet spot proposed by Dembek et al.
Results: Ten patients (10/36) were finally included in the study. ON-state with dyskinesias was characterized by a bilateral decrease in beta-band power (p<0.001) and a contralateral increase in theta (p=0.04) and gamma power (p=0.02). Beta oscillation decreases first, followed by theta power increase, which occurs immediately before dyskinesias. Gamma activity, on the other hand, increases after the initiation of dyskinesias. Our results also show that the decrease in beta-band power (p=0.03), and the increase in both theta (p=0.02) and gamma-band (p=0.002) power are maximal in the predefined sweet spot.
Conclusion: Our results provide novel insights into the bilateral modulation of beta-oscillation and the sequential nature of theta and gamma oscillatory changes. Given that theta-oscillation is contralateral and immediately precedes dyskinesias, it may be a key feature for training closed-loop protocols.
To cite this abstract in AMA style:
M. Wilken, L. Granda, I. Cruz Varela, M. Rossi, D. Cerquetti, M. Merello. Basal ganglia theta oscillation as a predictor of levodopa-induced dyskinesias [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/basal-ganglia-theta-oscillation-as-a-predictor-of-levodopa-induced-dyskinesias/. Accessed June 14, 2025.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/basal-ganglia-theta-oscillation-as-a-predictor-of-levodopa-induced-dyskinesias/