Category: Drug-Induced Movement Disorders
Objective: This investigation evaluates the effect of CA in orofacial dyskinesia in haloperidol-induced rat male model
Background: Orofacial dyskinesias are involuntary repetitive movements of the mouth and face. In traditional medicine from India, the bark decoction of Cinnamon is widely used for the treatment of diabetes mellitus (DM) either alone or in combination with other plants. Cinnamaldehyde (CA) is a diterpene with a wide range of anti-inflammatory, cognitive enhancer, anticancer, antileukemic and immunomodulatory actions, anti-diabetic effects thus may be advantageous in the treatment of cancer.
Method: Sixty male Wistar rats were randomly assigned into three groups. Group 1 was control, while groups 2 (10 mg/kg) and 3 (20 mg/kg) received CA orally once daily for 30 days. Rats were administered with haloperidol (1mg/kg, i.p for 21 days) to induce orofacial dyskinesia. Behavioral observations, vacuous chewing movements (VCM), tongue protrusions (TP), orofacial bursts (OB), grip strength, narrow beam walking) were assessed after haloperidol treatment. Biochemical parameters such as pro-inflammatory cytokines , tumor necrosis factor , antioxidant defense enzymes levels [superoxide dismutase and catalase], glutathione (GSH) levels, and malondialdehyde was studied in experimental-treated rats.
Results: Rats treated with haloperidol significantly decreased locomotion and developed VCMs, OBs, and TPs. Biochemical analysis reveals that haloperidol-treated rats also showed decreased levels of antioxidant enzymes and increase in lipid peroxidation levels in rats. Administration of CA (10 and 30 mg/kg, p.o.) along with haloperidol significantly reversed the effect on locomotion and restored biochemical parameters to normalcy.
Conclusion: It may conclude that CA could be screened as a therapeutic potential of drug for the prevention or treatment of neuroleptic-induced Orofacial dyskinesias.
To cite this abstract in AMA style:
S. -, V. Parcha. Beneficial effects of cinnamaldehyde in orofacial dyskinesia in haloperidol-induced rat model [abstract]. Mov Disord. 2022; 37 (suppl 2). https://www.mdsabstracts.org/abstract/beneficial-effects-of-cinnamaldehyde-in-orofacial-dyskinesia-in-haloperidol-induced-rat-model/. Accessed June 14, 2025.« Back to 2022 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/beneficial-effects-of-cinnamaldehyde-in-orofacial-dyskinesia-in-haloperidol-induced-rat-model/