Session Information
Date: Thursday, June 23, 2016
Session Title: Dystonia
Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To evaluate botulinum toxin A (BoNT-A) effectiveness on network in sensorimotor circuits.
Background: Involvement of many cerebellar structures, such basal ganglia, thalamus, cerebellum, premotor and primary sensorimotor cortical areas, is assumed in the pathophysiology of cervical dystonia (CD) and other focal dystonias. However, all of these pathophysiological mechanisms have not yet been fully explained. BoNT-A injections are recently the most effective, although symptomatic treatment of CD.
Methods: Twelve patients with CD and twelve age and gender matched healthy controls were examined with functional MRI during a skilled hand motor task before the initiation of regular BoNT-A injection therapy; the examination was repeated 4 weeks after the first BoNT-A injection to the dystonic neck muscles.
Results: Effective BoNT-A treatment led to reduced activation of the ipsilateral supplementary motor area (SMA) and dorsal premotor cortex. The post-treatment sensorimotor maps showed significantly smaller basal ganglia activation. In comparison with activation maps of control group were significant changes in patients group before initiation of BoNT-A injection, showing activation in many cerebral structures (thalamus, SMA, cerebellum, etc.). However results of second examination in the time of best effect of BoNT-A injection shows no significant changes in comparison with activation maps in the control group.
Conclusions: The results of the study support observations that the BoNT-A effect is manifested at the central nervous system level. The results show that abnormalities in sensorimotor activation extend beyond circuits controlling the affected body parts in CD. Results of this study show, that already first BoNT-A injection leads to “normalization” of sensorimotor activation. Research supported by Institutional Support of Research Organization MZ CR RV FNOL 2015. Supported by Ministry of Health of the Czech Republic, grant nr. 15-31921A. All rights reserved.
To cite this abstract in AMA style:
M. Nevrly, P. Hlustik, P. Otruba, P. Hok, Z. Tudos, P. Kanovsky. Botulinum toxin A injections changes sensorimotor network activations in cervical dystonia to state more related to physiological condition [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/botulinum-toxin-a-injections-changes-sensorimotor-network-activations-in-cervical-dystonia-to-state-more-related-to-physiological-condition/. Accessed May 18, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/botulinum-toxin-a-injections-changes-sensorimotor-network-activations-in-cervical-dystonia-to-state-more-related-to-physiological-condition/