Objective: To assess patient perceptions of and experiences with TD and its impact on their daily functioning and quality of life (QoL).

Background: There is a need to describe the psychosocial, emotional, economic, and professional burden of TD on patients in Australia, Brazil, China, and South Korea.

Method: Patients (aged ≥18 years) who self-reported a physician diagnosis of TD, experienced TD-related movements, and had a diagnosis of schizophrenia or schizoaffective disorder (SCZ), bipolar disorder (BD), or major depressive disorder (MDD) were recruited for a 20-minute online survey via online panels, social media, or physician referral (27 June through ‍17 October 2022).

Results: 435 patients in Australia (n=100), Brazil (n=85), China (n=150), and South Korea (n=100) were included in the study. 48% were male; mean (SD) age was 42.4 (11.7) years; years since first TD symptoms were 4.3 (4.0) and since TD diagnosis were 3.4 (3.5); 54% of respondents reported a diagnosis of SCZ, 47% BD, and 39% MDD. Overall, 47% of patients reported always or often developing additional psychiatric conditions (eg, anxiety) because of TD, 29% reported that their adherence with treatment for their underlying psychiatric condition was affected by TD, and 25% reported worsening of their underlying psychiatric condition because of TD. Patients reported that TD symptoms had a negative impact on their QoL; most patients always or often felt anxious or worried (59%) and/or sad or unhappy (54%). In addition, 41% of patients always or often limited their social activities because of TD, and 37% reported that TD impacted their ability to enjoy fun activities. Patients who were currently working (n=187) reported 15% absenteeism, 54% presenteeism, and 60% overall impairment while working, and 59% activity impairment. Overall, patients reported the greatest impact of TD on the psychological domain, followed by social and physical domains.

Conclusion: In this survey, patients reported that TD negatively affected their QoL across the psychological, social, physical, and occupational domains. These results indicate that TD could worsen the underlying psychiatric condition and limit patients’ social activities. Available TD treatments may help reduce the burden of TD on patients.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/burden-and-management-of-tardive-dyskinesia-td-a-cross-sectional-international-survey-study-to-assess-the-perceptions-and-experiences-of-patients-with-td/