Session Information
Date: Wednesday, June 22, 2016
Session Title: Parkinson's disease: Cognition
Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: Comparing cognitive and psychiatric outcome 3 years after bilateral deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) and subthalamic nucleus (STN) for advanced Parkinson’s disease (PD).
Background: DBS is an efficacious treatment for patients with advanced PD. The risks of cognitive and psychiatric side effects may influence the decision for either GPi or STN DBS.
Methods: Patients were randomized to receive GPi DBS (n=65) or STN DBS (n=63). Standardized test assessment was performed at baseline, 1 year, and 3 years. We used linear mixed model analyses to investigate between-group differences on the Mattis Dementia Rating Scale (MDRS), neuropsychological tests, and psychiatric questionnaires 3 years after DBS. Frequencies of psychiatric diagnoses resulting from the Mini-International Neuropsychiatric Interview (MINI) are reported without statistical testing.
Results: A total of 87 patients completed at least one neuropsychological test after 3 years (GPi 43, STN 44) and a total of 78 patients (61%) completed all neuropsychological tests. No significant between-group differences were found on the MDRS (p = 0.61), neuropsychological tests (p-values between 0.16 and 0.87), and psychiatric questionnaires (p-values between 0.29 and 0.88) 3 years after DBS. Results from the MINI indicated a reassuring low number of psychiatric diagnoses, though substance induced psychiatric disorders seem to occur more often after GPi DBS (GPi DBS: 5 out of 42 patients, STN DBS: 2 out of 45 patients).
Conclusions: Confirming the 1-year results from our trial, 3 years after DBS there are no pronounced between-group differences on measures of cognitive and psychiatric functioning. The larger number of substance induced psychiatric disorders in GPi DBS may be due to higher medication dosages compared to STN DBS.
To cite this abstract in AMA style:
J.A. Boel, V.J.J. Odekerken, G.J. Geurtsen, B.A. Schmand, M. Figee, R.J. de Haan, P. van den Munckhof, P.R. Schuurman, R.M.A. de Bie, The NSTAPS Study Group. Cognitive and psychiatric outcome 3 years after bilateral deep brain stimulation of the globus pallidus pars interna versus subthalamic nucleus for Parkinson’s disease [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/cognitive-and-psychiatric-outcome-3-years-after-bilateral-deep-brain-stimulation-of-the-globus-pallidus-pars-interna-versus-subthalamic-nucleus-for-parkinsons-disease/. Accessed June 14, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/cognitive-and-psychiatric-outcome-3-years-after-bilateral-deep-brain-stimulation-of-the-globus-pallidus-pars-interna-versus-subthalamic-nucleus-for-parkinsons-disease/