Category: Parkinson's Disease: Cognitive functions
Objective: We aimed to determine how the cognitive domains affect quality of life (QoL) in different cognitive states in PD.
Background: Parkinson’s disease with mild cognitive impairment (PD-MCI) or dementia (PDD) has been shown to be correlated with poor QoL. The association between specific cognitive domains and QoL is less clear.
Method: We recruited 600 PD patients, including 185 PD patients with normal cognition (PD-NC), 336 PD-MCI patients, and 79 PDD patients. All patients underwent a scale-based assessment (PDQ-39) for QoL, as well as clinical evaluations and neuropsychological tests.
Results: QoL was more impaired across the three groups (PD-NC < PD-MCI < PDD). Generalized linear model revealed that no neuropsychological test was significantly associated with QoL in PD-NC group; neuropsychological tests in attention and language domains were significantly associated with QoL in PD-MCI patients; neuropsychological tests in memory and language domains were significantly associated with QoL in PDD patients.
Conclusion: Cognitive domains contribute differently to QoL in PD. These findings may prompt clinicians to target specific cognitive domains for improving QoL in the PD patients.
To cite this abstract in AMA style:Y.L Tang, X.L Liang, LL. Han, J.T Yu, J. Wang. Cognitive function and quality of life in Parkinson’s disease: A cross-sectional study [abstract]. Mov Disord. 2020; 35 (suppl 1). https://www.mdsabstracts.org/abstract/cognitive-function-and-quality-of-life-in-parkinsons-disease-a-cross-sectional-study/. Accessed December 3, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/cognitive-function-and-quality-of-life-in-parkinsons-disease-a-cross-sectional-study/