Session Information
Date: Wednesday, September 25, 2019
Session Title: Non-Motor Symptoms
Session Time: 1:15pm-2:45pm
Location: Agora 3 West, Level 3
Objective: To investigate whether response to dopaminergic medication (DM) correlates to inhibitory cognitive control (IC) in patients with Parkinson’s disease (PD).
Background: In the MDS clinical diagnostic criteria for PD (1) a consistent good response to a high dose of DM is part of a clinical diagnosis of PD. However, patients with different subtypes of PD may still have a varying degree of response to medication. In this study we ask whether the response to DM has a cognitive behavioral correlation with respect to IC in PD subjects.
Method: After PROSPERO registration, the electronic databases Pubmed, Embase, Psycinfo and Cochrane Library were systematically searched. Broad selection criteria were applied since literature was expected to be limited. Two independent authors performed the search. Articles were eligible for inclusion if: (i) the article was in English, (ii) a quantitative assessment of IC was performed, (iii) a quantitative assessment of response to DM was performed, (iv) a group of at least 4 PD patients was investigated.
Results: The initial search for literature was performed on 19th December. The search yielded 12367 results. After screening for titles and abstracts, 77 studies were selected for full text analysis. After full text analysis no articles met the inclusion criteria. The response to DM is of interest as a lack of a good response to DM despite at least moderate severity of disease is listed as an exclusion criterion in the MDS diagnostic criteria for PD. A poor response to medication may point to a possible diagnosis of atypical Parkinsonism. However, subtypes of PD may have different or varying effects of medication.
Conclusion: Existing literature do not provide evidence to whether cognitive inhibitory control can be related to the effect of dopaminergic medication on motor symptoms in PD.
To cite this abstract in AMA style:
M. El Haddouchi, A. Handberg, K. Svaerke, A. Loekkegaard. Cognitive Inhibitory Control and Response to Dopaminergic Medication in Parkinson’s Disease [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/cognitive-inhibitory-control-and-response-to-dopaminergic-medication-in-parkinsons-disease/. Accessed June 15, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/cognitive-inhibitory-control-and-response-to-dopaminergic-medication-in-parkinsons-disease/