Objective: To look at the motor and non motor symptoms in patients with young onset and late onset Parkinson’s disease from an indian population.

Background: Parkinson’s disease is usually a disease of elderly but small percentage of population develop young onset Parkinson’s disease (≤ 50 years), there are ample differences between clinical features of YOPD and LOPD however very few studies were currently available from Indian population.

Method: We have retrospectively studied 101 patients with PD of which 53 are young onset PD patients (≤ 50 years) and 48 are late onset PD patients (> 50 years) with similar duration of disease. Clinical variables of both the groups were compared using Chi-square test and Student T test.

Results: A total of 101 patients were studied of which 30% were females. Micrographia, mood disturbances, insomnia were more frequent in younger group where as stooped posture and orthostatic hypotension was more frequent in older group. Motor severity scoring (UPDRS 3), disease staging (H&Y) and quality of life score (PDQ 39) were similar in both the groups. Non motor scores were higher in YOPD with a trend towards significance. Impulse control disorders were significantly higher in YOPD, while frontal lobe tests (stroop & trial B) were significantly worse in LOPD.

Conclusion: Significant differences exist between YOPD and LOPD patients. Autonomic and cognitive impairment are more common in LOPD, while non motor symptoms and impulse control disorder are higher in YOPD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/comparison-of-motor-non-motor-symptoms-impulse-control-disorders-and-quality-of-life-in-patients-with-young-versus-late-onset-parkinsons-disease/