Session Information
Date: Wednesday, June 7, 2017
Session Title: Neuropharmacology
Session Time: 1:15pm-2:45pm
Location: Exhibit Hall C
Objective: In the present investigation, we evaluated the effect of prenatal exposure of rats to lead from neonatal to adult age on the sensorimotor performances during development. Also, we evaluated the neuroprotective effect of curcumin I against lead neurotoxicity.
Background: Lead (Pb) is a heavy metal with no apparent biological function [1]. Pb is known to cause several damages in the central and peripheral nervous system [2], which could be manifested by several neurophysiological and behavioral outcomes [3-5].
Methods: Using grasping and cliff avoidance tests and Catwalk task, we evaluated the impairment of the sensorimotor functions in neonatal and young rats exposed prenatally to Pb.
Results: Our results showed that rats exhibit an impaired locomotor gait in Pb-treated from puppy and until young age. These abnormalities were strongly attenuated by curcumin I co-administration.
Conclusions: The present finding have brought evidence of a potent neuroprotective and restorative action of curcumin I against neuronal damages occurring during developmental exposition to heavy metals especially Pb, therefore, consumption of Curcumin I can be recommended as a possible pharmacological strategy for preventing Pb neurotoxicity.
References: 1.Fahr M, Laplaze L, Bendaou N, Hocher V, Mzibri ME, et al. Effect of lead on root growth.Front Plant Sci 6,4-175.Front Plant Sci. 2013; 6:4-175. doi: 10.3389/fpls.2013.00175 PMID: 23750165.
2. Bagchi D, Preuss HG. Effects of acute and chronic oval exposure of lead on blood pressure and bone mineral density in rats. J InorgBiochem. 2005; 99:1155 64. doi:10.1016/j.jinorgbio. 2005.02.011 PMID: 15833339.
3. Mameli O, Caria MA, Melis F, Solinas A, Tavera C, et al. Neurotoxic effect of lead at low concentrations. Brain Res Bull.2001; 15:269-75.doi:10.1016/S0361-9230 (01)00467-1 PMID: 11470326.
4. Chiodo LM, Jacobson SW, Jacobson JL. Neurodevelopmental effects of postnatal lead exposure at very low levels. NeurotoxicolTeratol.2004; 26:359-71.doi:10.1016/j.ntt.2004.01.010 PMID: 15113598.
5. Correa M, Roig-Navarro AF, Aragon CM. Motor behavior and brain enzymatic changes after acute lead intoxication on different strains of mice. Life Sci.2004; 74:2009-21. doi:10.1016/j.lfs.2003.08.042 PMID: 14967196.hea
To cite this abstract in AMA style:
H. BENAMMI, O. EL HIBA, H. GAMRANI. Curcumin I prevents the developmental defective sensorimotor patterns resulted from Lead poisoning in rat [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/curcumin-i-prevents-the-developmental-defective-sensorimotor-patterns-resulted-from-lead-poisoning-in-rat/. Accessed June 15, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/curcumin-i-prevents-the-developmental-defective-sensorimotor-patterns-resulted-from-lead-poisoning-in-rat/