Date: Monday, June 5, 2017
Session Title: Parkinsonism, MSA, PSP (Secondary and Parkinsonism-Plus)
Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective: To explore the features and determinants of depression and anxiety symptoms in multiple system atrophy (MSA) and the associations between mood dysfunction and quality of life (QOL) in MSA patients in Chinese population.
Background: Features and determinants of depression and anxiety symptoms in MSA and the associations between mood dysfunction and QOL in MSA patients in Chinese population remain unknown.
Methods: A total of 170 MSA patients were enrolled in the study. Neuropsychological assessment was performed using Hamilton Depression Rating Scale-24 items and Hamilton Anxiety Rating Scale. Parkinson’s Disease Questionnaire-39 item version was used to evaluate the QOL.
Results: We found that 64.1% and 71.7% patients had at least mild depression and anxiety symptoms, respectively. The severity of depression of MSA patients was associated with sex (P = 0.042), educational years (P = 0.030), disease duration (P = 0.001), disease severity (P = 0.007), orthostatic hypotension (P = 0.009) and global disability (P < 0.0001). While, the severity of anxiety was associated with increased disease duration (P < 0.0001), disease severity (UMSARS-I) (P = 0.020), orthostatic hypotension (P = 0.001) and global disability (P < 0.0001). Spearman’s correlation test showed both depression and anxiety symptoms had a close relationship with QOL in MSA patients. Binary logistic regression showed the determinants of depression were female, lower educational years, longer disease duration, orthostatic hypotension and global disability. Meanwhile, disease severity and orthostatic hypotension were the determinants of anxiety.
Conclusions: Depression and anxiety symptoms are common in patients with MSA. Both depression and anxiety symptoms have a close relationship with QOL in MSA patients. Neurologists should pay attention to depression and anxiety in patients with MSA, especially those with orthostatic hypotension and severe disease condition.
To cite this abstract in AMA style:L. Zhang, B. Cao, Q. Wei, R. Ou, B. Zhao, J. Yang, Y. Wu, H. Shang. Depression, anxiety and quality of life in Multiple System Atrophy [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/depression-anxiety-and-quality-of-life-in-multiple-system-atrophy/. Accessed December 3, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/depression-anxiety-and-quality-of-life-in-multiple-system-atrophy/