Objective: Parkinsonism is one of the commonest neurodegenerative diseases, which is characterized by a selective and progressive degeneration of dopaminergic neurons, causing a series of symptoms which might ultimately induce programmed cell death. In present study Floating tablets of alcoholic extracts of  Mucuna  pruriens, Bacopa  monniera, Centella  asiatica and Curcuma longa  were developed with an aim to prolong its gastric residence time and increase the bioavailability of drug.

Background: Various allopathic drugs such as Carbidopa,Levodopa, Benseraside, are used in the management ofParkinson disease but have serious side effects and also they are very costly as compared to herbal medicines whichhas very less side effects so we choose herbal drug for the management of Parkinson disease.

Method: Direct compression technique was used for the formulation of polyherbal floating tablets which consists of different compositions of Hydroxy Propyl Methyl Cellulose Micro Crystalline Cellulose (MCC) and Sodium bicarbonate (NaHCO3). Formulation was optimized on the basis of floating time and in vitro drug release. Parkinson’s disease was induced by administering haloperidol (1 mg/kg i.p. daily x 1 week).The mice of either sex were divided into different group (n =6). First group received distilled water (orally), 2nd group were administered haloperidol (20 mg/kg i.p.). The 3rd groups were administered optimized formulation respectively, along with haloperidol. Group 4th received Levodopa (30mg/kg, i.p,) along with haloperidol. Behavioural changes caused by haloperidol were studied by rotarod test, grip strength test and locomotor activity by actophotometer.

Results: The buoyancy time of all tablet formulations were found to be less than 10 min and remained in floating condition throughout the study, maximum till 12 hours. The optimized formulation was found to be f3 which was having buoyancy time of 4.2 min. The increased cataleptic scores (induced by haloperidol) were significantly (p<0.001) found to be more reduced with the f4 formulation as compared to negative control and standard treated group.

Conclusion: The optimized formulation shows sustained release of herbal constituents for more than 12 hours and In Vivo studies also showed its potential for the treatment of parkinsonism.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/development-of-anti-parkinsonism-poly-herbal-sustained-release-formulation-composed-of-potential-traditional-plant-extracts/