Objective: The purpose of this paper is to emphasize the importance of correct diagnosis in PSP.

Background: Progressive supranuclear palsy (PSP) is a commonly disease among Parkinson plus syndromes, and its early and accurate diagnosis is usually not possible.

Method: This study formed as retrospectively. 32 patients who were diagnosed as having PSP according to the National Institute for Neurological Disorders and Society for PSP (NINDS-SPSP) criteria  included in this study. Initial diagnosis of the patients and time course until correct diagnosis as PSP were assessed.

Results: The mean age of the patients was 65.83 years and 15 patients were female (46.8%) . Most of patients were diagnosed as Parkinson’s disease (PD) before correct diagnose.  All of the patients had supranuclear gaze palsy and postural instability. The median time from onset of symptoms to diagnosed as PSP was 4.1 years (2.4-5.9).

Conclusion: Our results suggest that the correct diagnosis of PSP has taken after several years. Diagnostic criteria should be expanded and developed for earlier recognition of PSP.

References: 1- Lang AE. Clinical heterogeneity in progressive supranuclear palsy: challenges to diagnosis, pathogenesis and future therapies. Mov Disord 2014; 29:1707-1709. 2- Respondek G, Hoglinger GU. The phenotypic spectrum of progressive supranuclear palsy. Parkinsonism Related Disord 2016; 22:34-36. 3- Hoglinger GU, Respondek G, Stamelou M et al. Movement Disorder Society-endorsed PSP Study Group. Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria. Mov Disord 2017; 32:853-864.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/diagnostic-accuracy-of-progressive-supranuclear-palsy-experience-of-a-movement-disorders-center/