Objective: This study explores the value of α-Syn, Aβ1-42, t-tau, p-tau181 in cerebrospinal fluid(CSF) and their ratios for the diagnosis of Parkinson’s disease with mild cognitive impairment (PD-MCI).

Background: There are no a biomarker distinguish PD-MCI from PD with normal cognition(PD-NC).

Method: Fifty-three patients with PD and twenty four healthy controls were recruited in the study. The clinical data were collected. According to the Level-II level in the diagnostic criteria for PD-MCI as published by MDS, all non-dementia PD patients were divided into PD-NC group (27 cases) and PD-MCI group (26 cases). ELISA method was used to detect the levels of biomarkers in CSF. We performed their correlation analysis with cognition and receiver operating characteristic (ROC) curve analysis to assess the diagnostic accuracy of the most discriminative indicators of disease status.

Results: This study found no differences in clinical data such as age, gender, education level, course of disease, H&Y stage, HAMA, HAMD among the three groups (P> 0.05). MMSE and MoCA scores of patients in the PD-MCI group were significantly lower than those in the PD-NC and HC groups (P <0.01) (see Table 1). There were no statistical differences in the distribution of Aβ1-42, P-tau181/Aβ1-42, t-tau/Aβ1-42, P-tau181/α-Syn (P> 0.05) among the three groups. α-Syn, α-Syn/Aβ1-42 were decreased significantly in PD-MCI compared with HC group (P <0.05); t-tau (P = 0.013), t-tau/P-tau181(P <0.001) in PD -MCI was significantly higher than PD-NC and HC; p-tau181 (P = 0.004), t-tau/α-Syn (P = 0.001) were significantly higher in PD-NC and PD-MCI than in HC group(see Table 2 and Figure 1). Further analysis found that the increase of t-tau/p-tau181 in PD patients was related to the decline in the block design scale score (P = 0.017) and logical memory scale score (P = 0.043) (see Table 3). It was found that the area under the ROC curve of t-tau protein to diagnose PD-MCI is 0.670 (P = 0.015), and the sensitivity and specificity is 69.2%, 56.9%,respectively. The t-tau/p-tau181 used to diagnose PD-MCI had an area under the ROC curve of 0.768 (P <0.001), the sensitivity and specificity is 80.8%, 68.6%, respectively (see Figure 2).

Conclusion: The t-tau/p-tau181 has a higher sensitivity and Specificity in identifying PD-MCI.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/diagnostic-utility-of-cerebrospinal-fluid-t-tau-p-tau181-in-parkinsons-disease-with-mild-cognitive-impairment-a-cross-sectional-study-in-chinese-cohort/