Senile Plaques and Neurofibrillary Tangles Modulate Lewy Body Distribution: Autopsy Study of 2,308 Cases
Objective: To understand how Lewy body (LB) pathology progresses in the cerebrum and how Alzheimer's disease (AD) pathology influences LB distribution in LB disease (LBD).…Amygdala-predominant Lewy Body Disease is a Lens for Understanding Pathogenesis and the Alpha-synuclein Seeding Assay in Human Postmortem Brain
Objective: To map alpha-synuclein (asyn) and tau markers in amygdala-predominant Lewy body disease (AP-LBD), identifying spread pathways and vulnerable cell populations. Background: LBD often co-occurs…Sex Moderates the Effects of Neurofibrillary Tangles on Cognition for Diffuse Lewy Body Pathology
Objective: To evaluate (1) the association between neurofibrillary tangle staging and cognition for participants with diffuse Lewy Body (LB) pathology, (2) whether this association differs…Diagnostic utility of cerebrospinal fluid t-tau/p-tau181 in Parkinson’s disease with mild cognitive impairment: A cross-sectional study in Chinese cohort
Objective: This study explores the value of α-Syn, Aβ1-42, t-tau, p-tau181 in cerebrospinal fluid(CSF) and their ratios for the diagnosis of Parkinson's disease with mild…The ADNPC-RS: a risk score that identifies Lewy body disease individuals at risk for developing concomitant Alzheimer’s pathology
Objective: To identify which common genetic variants that confer risk for Alzheimer’s disease (AD) also predict the development of concomitant AD pathology in patients with…18F-AV-1451 PET imaging in pre-dementia Parkinson’s disease
Objective: To describe cortical and subcortical 18F-AV-1451 binding in Parkinson’s disease patients with and without mild cognitive impairment (PD-MCI and PD-nonMCI). Background: The radioligand 18F-AV-1451…The clinical profile associated to Amyloid-beta 42 and Tau cerebrospinal fluid levels in non-demented PD patients
Objective: To define cerebrospinal fluid (CSF) levels of Amyloid-beta 1-42 (Aß1-42-), total (h-) and phosphorylated (p-)Tau in a large cohort of non-demented Parkinson’s disease (PD)…Phosphorylation by GSK-3β enhances binding of metal ion induced tau oligomers to neutral lipid surfaces
Objective: To dissect the complex interplay of tau hyperphosphorylation, metal ion induced oligomer formation and membrane interactions applying single particle fluorescence techniques. Background: Fibrillar deposits…Tau pathology in Huntington’s disease: A brief in vivo PET-imaging report
Objective: To assess feasibility of measuring pathological tau deposition in patients with Huntington's disease (HD) using [18F]-AV-1451 (f.k.a. T807) PET. Background: HD is a progressive…In vivo evaluation of tau pathologies in patient with progressive supranuclear palsy and healthy subjects with [11C]PBB3-PET
Objective: This study was aimed at evaluating pathological tau accumulations in the brains of patients with progressive supranuclear palsy (PSP) and young and old healthy…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.