Category: Parkinson's Disease: Cognitive functions
Objective: To investigate motor, non-motor and cognition progression in early PD patients with Mild Cognitive Impairment (MCI) and normal cognition over 5 years.
Background: The longitudinal studies of mild cognitive impairment (MCI) in Parkinson Disease (PD) patients mainly focused on depicting the cognitive trajectories. Little is known about the comprehensive profile of disease progression in PD-MCI patients.
Method: PD patients were enrolled from Early Parkinson’s disease Longitudinal Singapore (PALS) cohort and classified into PD-MCI group and PD patients with normal cognition (PD-NC) group according to the MDS Level II criteria. All the PD patients were followed up annually up to 5 years. H&Y staging scale, MDS-UPDRS part III motor score and postural instability gait difficulty (PIGD) score were used to assess disease severity and motor progression. Non-motor symptom scale (NMSS) was used to evaluate the NMS progression. Cognitive progression was assessed from 5 cognitive domains. Annual progression changes in the longitudinal outcomes were examined via linear mixed model with random intercept effect.
Results: A total of 205 PD patients, including 107 PD-MCI and 98 PD-NC patients were assessed prospectively over a 5-year period. PD-MCI patients, compared to PD-NC group, had a significantly higher progression rate in H&Y score (0.11 vs 0.06, p=0.03), UPDRS motor score (3.11 vs 1.90 p<0.001) and PIGD score (0.40 vs 0.20, p=0.02). PD-MCI group also exhibited significantly faster deterioration in NMSS perceptual problems/ hallucination domain (PD-MCI vs PD-NC: 0.38 vs -0.04, p=0.01) and cognitive visuospatial domain (PD-MCI vs PD-NC: 0.13 vs -0.06, p=0.048).
Conclusion: PD-MCI patients had faster decline in motor functions, visuo-perceptual and visuospatial performance. These findings provide a more comprehensive prognosis of PD-MCI, which could be helpful for clinician to manage PD-MCI patients.
To cite this abstract in AMA style:
X. Deng, S. Saffari, S. Ng, N. Chia, X. Choi, D. Heng, B. Xiao, Z. Xu, K. Tay, W. Au, N. Liu, E. Tan, L. Tan. Disease progression in Parkinson‘s disease patients with Mild Cognitive Impairment: 5-year longitudinal study from The Early Parkinson’s disease Longitudinal Singapore (PALS) cohort [abstract]. Mov Disord. 2023; 38 (suppl 1). https://www.mdsabstracts.org/abstract/disease-progression-in-parkinsons-disease-patients-with-mild-cognitive-impairment-5-year-longitudinal-study-from-the-early-parkinsons-disease-longitudinal-singapore-pals-cohort/. Accessed July 15, 2025.« Back to 2023 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/disease-progression-in-parkinsons-disease-patients-with-mild-cognitive-impairment-5-year-longitudinal-study-from-the-early-parkinsons-disease-longitudinal-singapore-pals-cohort/