MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

MENU 
  • Home
  • Meetings Archive
    • 2024 International Congress
    • 2023 International Congress
    • 2022 International Congress
    • MDS Virtual Congress 2021
    • MDS Virtual Congress 2020
    • 2019 International Congress
    • 2018 International Congress
    • 2017 International Congress
    • 2016 International Congress
  • Keyword Index
  • Resources
  • Advanced Search

Disrupted Amplitude of Low-frequency Fluctuations and Causal Connectivity in Parkinson’s Disease with Apathy

Y. Shen, J. Li, Y. Yuan, X. Wang, M. Wang, J. Wang, H. Zhang, L. Zhu, K. Zhang (Nanjing, China)

Meeting: 2018 International Congress

Abstract Number: 1782

Keywords: Apathy, Parkin

Session Information

Date: Monday, October 8, 2018

Session Title: Parkinson's Disease: Psychiatric Manifestations

Session Time: 1:15pm-2:45pm

Location: Hall 3FG

Objective: We aimed to explore associated neural substrates changes in Parkinson’s disease (PD) with apathy via amplitude of low-frequency fluctuations (ALFF) and Granger Causality Analysis (GCA).

Background: Apathy, as an affective, cognitive, and behavioral syndrome, is a common non-motor symptom in PD. Although a set of studies have investigated its possible pathogenesis, the results were quite different, which couldn’t come to a consistent conclusion.

Methods: 42 PD patients were finally recruited, including 20 patients with apathy (PD-A) and 22 patients without apathy (PD-NA). In addition, we recruited 19 healthy controls (HCs). All subjects were evaluated for demographic and clinical characteristics and performed 3.0 T MRI scans. GCA, a new method exploring direction from one brain region to another in resting-state functional magnetic resonance imaging (rs-fMRI), was based on brain regions showing alterations of neural activity as seeds, which were examined utilizing ALFF approach.

Results: Relative to PD-NA group, PD-A group indicated decreased ALFF in left orbital middle frontal gyrus and bilateral superior frontal gyrus (SFG). Only ALFF values in right SFG were negatively correlated with Apathy Scale (AS) scores. Then GCA with the seed of right SFG showed a positive feedback from right thalamus to ipsilateral SFG, which positively correlated with AS scores.

Conclusions: We hypothesized that dysfunction in SFG and a positive feedback from thalamus to ipsilateral SFG might contribute to PD-related apathy. Our speculation might provide a new perspective for future study on apathy in PD.

To cite this abstract in AMA style:

Y. Shen, J. Li, Y. Yuan, X. Wang, M. Wang, J. Wang, H. Zhang, L. Zhu, K. Zhang. Disrupted Amplitude of Low-frequency Fluctuations and Causal Connectivity in Parkinson’s Disease with Apathy [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/disrupted-amplitude-of-low-frequency-fluctuations-and-causal-connectivity-in-parkinsons-disease-with-apathy/. Accessed July 10, 2025.
  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2018 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/disrupted-amplitude-of-low-frequency-fluctuations-and-causal-connectivity-in-parkinsons-disease-with-apathy/

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • What is the appropriate sleep position for Parkinson's disease patients with orthostatic hypotension in the morning?
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • Life expectancy with and without Parkinson’s disease in the general population
  • To be or not to bupropion: a drug-induced parkinsonism?
  • Estimation of the 2020 Global Population of Parkinson’s Disease (PD)
      • Help & Support
      • About Us
      • Cookies & Privacy
      • Wiley Job Network
      • Terms & Conditions
      • Advertisers & Agents
      Copyright © 2025 International Parkinson and Movement Disorder Society. All Rights Reserved.
      Wiley