Session Time: 1:15pm-2:45pm
Location: Les Muses Terrace, Level 3
Objective: Our aim was to investigate the changes in dynamic functional connectivity in the brain of such patients, as well as the topological properties.
Background: Dynamic functional connectivity research in Parkinson´s disease (PD) suggests an abnormal global integration of the brain networks. Although dynamic analysis could help better understand the alterations to neurocognitive reward system in PD patients with impulse control disorders (ICD), there is no previous study in the field.
Method: Resting state functional magnetic resonance imaging was performed on 16 PD patients with ICD (PD-ICD), 20 PD patients without ICD and 17 healthy controls, whose demographic, clinical and behavioral (especially impulsivity) scores were also assessed. A group spatial independent component analysis was applied, as well as a sliding windows approach and graph-theory analysis.
Results: Dynamic functional connectivity analysis identified four connectivity configurations or states, the most frequent being a within-network state (State III) with stronger connections in the sensorimotor, visual and cognitive-salience networks (Figure1). PD-ICD patients maintained State III for longer periods, which was positively correlated with their performance in clinical impulsivity and novelty seeking scales (Figure2). In this state, these patients also showed stronger connections and stronger local efficiency in areas of the salience network.
Conclusion: The findings presented here suggest that local re-occurrence of the information in reward processing areas is maintained in PD-ICD patients, which is associated with impulsivity measures and personality traits. These data suggest a brain reorganization where reward-related regions acquire a prominent role, providing new insights into the role of dynamic analysis in the pathophysiology of these patients.
To cite this abstract in AMA style:I. Navalpotro-Gomez, J. Kim, PM. Paz-Alonso, M. Delgado-Alvarado, A. Quiroga-Varela, H. Jimenez-Urbieta, M. Carreiras, AP. Strafella, MC. Rodriguez-Oroz. Disrupted salience network dynamics in Parkinson´s disease patients with impulse control disorders [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/disrupted-salience-network-dynamics-in-parkinsons-disease-patients-with-impulse-control-disorders/. Accessed December 9, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/disrupted-salience-network-dynamics-in-parkinsons-disease-patients-with-impulse-control-disorders/