Objective: To study if there is link between camptocormia (CC) and fatigue syndrome (FS) in PD patients.

Background: There is still no consensus on etiology and pathogenesis of camptocormia and fatigue syndrome in patients with Parkinson’s disease (PD). Whether patients with FS are more prone to CC still needs further investigation.

Methods: 120 patients with PD were examined. Following methods were applied: MDS-UPDRS, PD’s fatigue scale (PFS). CC was diagnosed when thoracolumbar flexion exceeded 45°. PFS score > 3.3 was considered as pathological. 2 groups of patients were formed: with FS and without FS. Middle age of patients was 67,5±4,5 and 66,9±5,5. PD’s stage was 3,6±0,5 and 3,45±1,1, disease’s duration was 6,9±4,04 and 5,4±2,85 correspondingly.

Results: Among patients with FS CC occurred in 56% cases, in the control group in 23%. Postural instability was diagnosed in 54% among patients with FS, and in 37% among patients of the other group. Mean MDS-UPDRS score in the group with FS was 83,82 ± 26,44, in the group without FS mean MDS-UPDRS score was 68,15 ± 35,41.

Conclusions: This study shows that patients with FS more often have CC, then patients without FS. This fact can imply that both complications may have same pathological pathways, linked with central and peripheral mechanisms. Further studies of these phenomenon will provide with more effective treatments.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/does-link-between-fatigue-syndrome-and-camptocormia-in-patients-with-parkinsons-disease-exist/