Session Information
Date: Wednesday, June 22, 2016
Session Title: Phenomenology and clinical assessment of movement disorders
Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To evaluate an instrumented version of Timed Up and Go Test (iTUG) in patients with Parkinson’s disease (PD), both in L-dopa OFF and ON-state.
Background: TUG is a widely used clinical test for the evaluation of balance and mobility. iTUG has been proposed to provide quantitative information on TUG performances. Here, we hypothesized that L-dopa may differently influence gait parameters recorded by a portable inertial sensor.
Methods: PD patients were instructed to perform iTUG three times both in practical OFF and ON-state. During the TUG test, patients wore a portable system consisting in a wireless network of inertial sensors. The system differentiates the test in six phases, recording phases durations, three-axial accelerations, average and peak angular speeds during turning.
Results: Twenty-eight PD patients were enrolled (age: 66.3 ± 8.5 years; Hoehn-Yahr stage: 2.2 ± 0.4). Eight patients had freezing of gait responsive to L-dopa. In all patients, sit-to-stand duration and medio-lateral acceleration together with turning phases duration and angular speeds improved after L-dopa administration, while sit-to-stand and stand-to-sit phases antero-posterior accelerations were less responsive. Freezers got worse results compared to non-freezers. Sit-to-stand and stand-to-sit vertical accelerations did not respond to L-dopa in freezers differently from non-freezers. L-dopa acute effects on mid-turning and turning-before-sitting duration and angular speeds were instead prominent in freezers.
Conclusions: In PD, L-dopa less modulates postural controls during the sit-to-stand and stand-to-sit phases, especially in responsive freezers. Motor performances during turning are instead significantly modulated by L-dopa in responsive freezers.
XLVI Congress of the Italian Society of Neurology, October 10-13, 2015. 1st Congress of LIMPE-DISMOV Academy, September 28-30, 2015.
To cite this abstract in AMA style:
V. Dibilio, A. Nicoletti, G. Mostile, S. Toscano, A. Luca, L. Raciti, R. Vasta, C.E. Cicero, D. Contrafatto, M. Zappia. Dopaminergic and non-dopaminergic effects on instrumented timed up and go test in patients with Parkinson’s disease [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/dopaminergic-and-non-dopaminergic-effects-on-instrumented-timed-up-and-go-test-in-patients-with-parkinsons-disease/. Accessed June 14, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/dopaminergic-and-non-dopaminergic-effects-on-instrumented-timed-up-and-go-test-in-patients-with-parkinsons-disease/