Session Information
Date: Tuesday, June 21, 2016
Session Title: Drug-induced movement disorders
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To review drug-induced parkinsonism (DIP) in Taiwan.
Background: Drug-induced parkinsonism (DIP) is a frequent etiology of secondary parkinsonism. DIP must always be suspected when Parkinsonian symptom like rigidity, tremor, or postural instability appear in patients receiving drug treatment. Indeed, the main causative drugs are antipsychotic, other neuroleptic drugs, and calcium-channel entry blockers. The risk associated with antipsychotics is often dose dependent and related to dopamine D2 striatal occupancy.
Methods: We retrospectively review the clinically demographic data of DIP registered in Movement Disorders Clinic of three hospitals in Taiwan between August 1997 and July 2015, two from urban area and another one from rural area.
Results: During these 18 years, 1377 parkinsonism have been registered, including 300 (21.8%) cases of DIP. The frequency of DIP in parkinsonism patients from urban area is 9.2%, but it is 28.7% in rural hospital. DIP is significantly more frequent in woman (63%) and the ratio of woman to man is 1.7. Mean onset age of DIP is 73.4±10.8 years. The most common involved age of patients are between 70 and 79 years (44.7%), followed with age of 80 and 89 years (29%). The calcium channel blockers (42.8 %) is the most frequent pharmacological group to cause DIP, followed by dopamine D2 receptor antagonists (33.9%). Flunarizine (calcium channel blocker) is the most common potentially responsible drug for DIP in this study, followed by sulpiride (dopamine D2 receptor antagonist), dilitiazem (calcium channel blocker), flupentixol (anti-depressant), metoclopramide (anti-emetic drug), risperidone (atypical anti-psychotic drug) and haloperidol (dopamine D2 receptor antagonist). The risk factor for DIP in this study include elderly (age ≥ 70 years), woman, living in rural area, Low education, dementia, hemiballism-hemichorea and oromandibular dyskinesia.
Conclusions: DIP is a common etiology for patients with parkinsonism in Taiwan, particularly in those elderly women (age more than 70 years) living in rural area.
To cite this abstract in AMA style:
J.J. Lin, K.C. Yueh, A.C. Chen. Drug-induced parkinsonism in Taiwan [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/drug-induced-parkinsonism-in-taiwan/. Accessed June 14, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/drug-induced-parkinsonism-in-taiwan/