Session Information
Date: Monday, June 20, 2016
Session Title: Surgical therapy: Parkinson's disease
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: In this 1-year prospective study, we evaluated the effect of bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) on neuropsychiatric complications of Parkinson’s disease (PD), including impulse control disorders (ICD), depression, apathy, anxiety, anhedonia. [table1]
Background: There are various data on the effect of STN-DBS on behavioral complications of PD. Either improvement or worsening after surgery of ICD, depression, apathy, anxiety, anhedonia has been reported.
Methods: A consecutive series of 19 PD patients (disease duration: 10.7±4.1 years; age: 47.5±6.7 years) were evaluated longitudinally before surgery and 3, 6, 12 months after bilateral STN-DBS. Behavioural evaluation included the following scales: Hamilton Rating Scale for Depression, (HDRS), The Hamilton Anxiety Rating Scale, (HARS), Snaith-Hamilton-Pleasure-Scale, (SHAPS), apathy scale Starkstein S. et al., (ASS), for Impulsive-Compulsive Disorders in Parkinson’s disease (QUIP), Parkinson´s Disease Quality of Life-39 Scoring System, (PDQ-39).
Results: 11/19 patients presented at least one ICD at baseline, most frequently punding. At last follow-up, dopamine dysregulation syndrome disappeared in 5/5, gambling in 3/5, compulsive shopping in 7/8 and hepersexuality 4/6. New onset hypersexuality occurred just in one patient at 3 months follow-up, with resolution up to 9-months years switching from ventral to dorsal stimulation. Severity of the following ICD significantly decreased over time: dopamine dysregulation syndrome, gambling, compulsive shopping and hepersexuality. Reduction of levodopa and dopamine agonists equivalent daily dose was associated to significantly improvement of ICD after surgery.
Conclusions: Based on our observations, we can conclude that successful STN-DBS is efficacious in treating behavioral symptoms associated to PD, through a decrease of dopaminergic medications.
To cite this abstract in AMA style:
S.M. Omarova, N.V. Fedorova, E.V. Bril, A.A. Tomskiy, A.A. Gamaleya. Effect of STN-DBS on impulse control disorder and affective behavioral complications of Parkinson’s disease: A 1-year longitudinal study [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/effect-of-stn-dbs-on-impulse-control-disorder-and-affective-behavioral-complications-of-parkinsons-disease-a-1-year-longitudinal-study/. Accessed May 14, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/effect-of-stn-dbs-on-impulse-control-disorder-and-affective-behavioral-complications-of-parkinsons-disease-a-1-year-longitudinal-study/