Session Information
Date: Wednesday, June 7, 2017
Session Title: Parkinson's Disease: Psychiatric Manifestations
Session Time: 1:15pm-2:45pm
Location: Exhibit Hall C
Objective: This study aims to identify markers for emotional and cognitive dysfunctions in Parkinson’s disease (PD) using non-invasive electroencephalography (EEG). This study investigates event related potential (ERPs) elicited when evaluating for valence judgements on negative and neutral target words in an automatic affective priming paradigm, and examines correlates with depression and cognitive impairment scores.
Background: Neural mechanisms underlying common neuropsychiatric deficits such as depression and cognitive impairment are poorly understood in PD. EEGs are better tolerated by patients with PD, allows recordings of neural events as they unfold at a millisecond time frame, and may serve as potential markers for improving diagnostic accuracy and monitoring disease progression.
Methods: Fifty non-demented PD patients unmedicated for depression or anxiety completed an affective priming task while EEG was simultaneously recorded. The paradigm presented prime and target word pairs of negative or neutral valence at a 250ms interval. Participants were asked to evaluate the valence of the target word by button press. Depression, anxiety, and cognitive impairment were measured using rating scales. Repeated measures ANCOVA and correlational analyses were performed and examined whether ERPs varied as a function of depression, anxiety and cognitive impairment.
Results: Key findings were, reduced central parietal Pz-P300 and LPP difference waves between congruent and incongruent neutral targets in patients with higher depression scores, reduced Pz- N400 difference waves between incongruent and congruent neutral targets in patients with higher depression scores and cognitive impairment scores, and a loss of left central Slow Negative Wave (SNW) in patients with higher cognitive impairment scores.
Conclusions: The present study identifies ERP markers relating to emotional and cognitive dysfunction in PD, and advances knowledge in the neural underpinning of these common neuropsychiatric deficits in PD.
To cite this abstract in AMA style:
N. Dissanayaka, T. Au, A. Angwin, J. O'Sullivan, G. Byrne, P. Silburn, R. Marsh, G. Mellick, D. Copland. Electrophysiological markers for emotional and cognitive impairment in Parkinson’s disease [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/electrophysiological-markers-for-emotional-and-cognitive-impairment-in-parkinsons-disease/. Accessed June 15, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/electrophysiological-markers-for-emotional-and-cognitive-impairment-in-parkinsons-disease/