Session Information
Date: Tuesday, June 6, 2017
Session Title: Education in Movement Disorders
Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective: Sequence analysis of genes involved in acetylcholinesterase inhibitors biosynthesis from various plant species
Background: The neurodegenerative disease like Alzheimer’s disease and Parkinson’s disease involve the deterioration of central nervous system caused by rapid hydrolysis of the neurotransmitter such as acetylcholine. The plant kingdom possesses a vast variety of natural compounds that have antineurodegenerative function, and have fewer side effects; extracts of a number of medicinal plants (such as Withania) have shown significant antineurodegenerative properties. The plant derived acetylcholinesterase inhibitors (AChEi), mainly alkaloids, have shown significant downregulation of acetylcholinesterase thereby increasing the acetylcholine level in brain. There is also a significant correlation between acetylcholinesterase inhibition and observed cognitive improvement.
Methods: In this study, Sequence homology and phylogenetic analysis has been performed by using NCBI database, ClustlW and MEGA 6.0 software.
Results: Sequence analysis of genes involved in acetylcholinesterase inhibitors biosynthesis from various plant species revealed their evolutionary conservation. In silico studies of these enzyme inhibitors also provided insight to the domain organization and various important motifs present in sequences.
Conclusions: Sequence analysis based on homology and conservation of genes for acetylcholinesterase inhibitors may lead to the effective drug designing for treatment of Alzheimer’s disease and associated disorders.
References: Russo D, Valentão P, Andrade PB, Fernandez EC, Milella L 2015, Evaluation of Antioxidant, Antidiabetic and Anticholinesterase Activities of Smallanthus sonchifolius Landraces and Correlation with Their Phytochemical Profiles. Int J Mol Sci. Jul 31;16(8):17696-718
To cite this abstract in AMA style:
N. No surname, M. Abdin. Exploiting sequence data of genes involved in synthesis of plant derived enzyme inhibitors of Acetylcholinesterase that involve in antineurodegenerative acitivity. [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/exploiting-sequence-data-of-genes-involved-in-synthesis-of-plant-derived-enzyme-inhibitors-of-acetylcholinesterase-that-involve-in-antineurodegenerative-acitivity/. Accessed June 15, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/exploiting-sequence-data-of-genes-involved-in-synthesis-of-plant-derived-enzyme-inhibitors-of-acetylcholinesterase-that-involve-in-antineurodegenerative-acitivity/