Objective: To identify factors related to a worse health-related and global perceived quality of life (QoL) in a cohort of Parkinson´s disease (PD) patients and compare to a control group.

Background: Currently there is no cure for PD and the aim of medications is to improve QoL of patients. So, it is very important to identify determinant factors that can be modified in order to improve the patient´s QoL.

Methods: The data correspond to the baseline evaluation of the COPPADIS-2015 Study, an observational, descriptive, 5-year follow-up, national (Spain), multicenter, evaluation study (Santos García et al. BMC Neurol 2016). Three different instruments were used to assess QoL: 1) the 39-item Parkinson’s disease Quality of Life Questionnaire (PDQ-39), 2) a subjective rating of global perceived QoL (PQ-10) on a scale from 0 (worst) to 10 (best) and 3) the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Multiple linear regression methods were used to evaluate the direct impact of different variables on these QoL meaures.

Results: QoL was worse in PD patients (n=696; 62.8 ± 9 years old, 59.8% males) than controls (n=205; 61.2 ± 8.5 years old, 47.4% males): PQ-10, 7.3 ± 1.6 vs 8 ± 1.3 (p<0.0001); EUROHIS-QOL8, 30.3 ± 4.4 vs 33.8 ± 4.1 (p<0.0001). Moderate to strong correlations were observed between the three scales (from r=-0.488 to r=0.677; p<0.0001). A high correlation between PDQ-39 and Non-Motor Symptoms Scale (NMSS) was found (r=0.775; p<0.0001), whereas association was lower with other measures in the study. For health-related QoL, non-motor symptoms burden (NMSS), mood (Beck Depression Inventory II) and gait problems (Freezing of Gait Questionnaire) provided the highest contribution to the model (β = 0.295, 0.269 and 0.169, respectively; p<0.0001; adjusted R-squared 0.658) whereas mood and gait problems for global perceived QoL (PQ-10, β = -0.374 and -0.149, respectively [adjusted R-squared 0.305]; EUROHIS-QOL8, β = -0.380 and -0.225, respectively [adjusted R-squared 0.500]).

Conclusions: QoL is worse in PD patients than controls. Mood, non-motor symptoms burden and gait problems seem to be the most relevant factors affecting health-related and global perceived QoL in PD patients.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/factors-affecting-quality-of-life-in-patients-with-parkinsons-disease-motor-vs-non-motor-symptoms-results-from-the-coppadis-study-cohort/