Objective: To analyze hospital admission patterns among patients with Parkinson’s Disease (PD), comparing demographic characteristics, reasons for admission, length of stay, and discharge disposition between male and female patients.

Background: Patients with PD have a higher risk of hospitalization compared to the general population. Understanding the factors influencing their admissions may help optimize care and resource allocation.

Method: Data from the National Inpatient Sample (NIS) was analyzed, including 1,388,055 PD patients admitted between 2016 and 2019, identified using International Classification of Diseases, 10th Edition (ICD-10) codes. Additionally, records of 211 PD patients admitted to Westchester Medical Center (WMC) between January 2023 and July 2024 were reviewed. Admission diagnoses, demographics, and discharge dispositions were compared between male and female patients. Multivariate logistic regression was conducted to examine differences in length of hospital stay, complications, and discharge disposition, adjusting for age.

Results: Among 1,388,055 PD patients, more males (58.5%) were hospitalized than females (41.5%). The most common admission diagnoses were urinary tract infection (UTI, 4.8%), hip fracture (3.2%), pneumonia (3.2%), and deep brain stimulation (DBS) procedures with insertion of neurostimulator lead (1.1%). Females had higher rates of hip fracture, UTI, congestive heart failure, stroke, and constipation, while males were more commonly admitted for pneumonia and DBS. Among 15,090 patients admitted for DBS, 68.3% were male and 31.7% were female. At WMC, among 211 PD patients, the primary reasons for admission included falls (with or without fracture or intracranial hemorrhage), infections (pneumonia, UTI), cardiovascular conditions, behavioral disturbances, and DBS-related procedures. More males were admitted than females (63.98% vs. 36.02%). While no significant differences in age or discharge disposition were observed, males had a longer hospital stay than females (8.8 days vs. 6.8 days, p<0.05).

Conclusion: Males with PD were more frequently hospitalized than females, with differences in primary reasons for admission and length of hospital stay. These findings highlight the need for targeted interventions to reduce hospitalization risk and improve outcomes in PD patients.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/gender-based-differences-in-parkinsons-disease-hospitalization-a-nationwide-and-single-center-study/