Session Information
Date: Monday, June 20, 2016
Session Title: Parkinsonism, MSA, PSP (secondary and parkinsonism-plus)
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: Assess the heart rate (HR) coefficient of variance (CV) in three conditions: supine, active standing and during deep breathing; and measure the sympathetic skin response in patients with Parkinson plus syndrome (PPs), Parkinson’s disease (PD), Multiple System Atrophy (MSA) and healthy subjects to compare their differences.
Background: Autonomic dysfunction has a major impact in quality of life, performing a cardiovascular autonomic nervous system evaluation is useful for prognosis in Parkinsonian disorders and even can help in the differential diagnosis.
Methods: Retrospectively we identified patients attending the Clinical Neurophysiology department of Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, from june 1st 2011 to july 30 2014. We assess the CV during 2 minutes of resting supine, deep breathing at 6 Hz, and the 30:15 index was obtained from active standing maneuver. Sympathetic skin response was obtained from palms and soles and latency and amplitude were measured. ANOVA was performed among groups to assess differences using SigmaStat V3.5, p<0.5 was considered statistically significant.
Results: We found records of 13 Parkinson’s disease patients, 8 MSA patients, 12 PPs, and 11 healthy controls. CV in supine was: 15.7 in healthy individuals vs 10.2 y 9.6 in PD and AMS (p=0.009). 30:15 index: healthy controls was 1.26 ± 0.1 vs 1.07± 0.07, 1.12 ± 0.09 y 1.09 ± 0.07 in PDs, AMS y PPs, respectively (p<0.001). CV during Deep breathing: 23.4 in healthy controls vs 15.3 and 13.4 in AMS y PPs (p=0.008). Sympathetic skin response latency in palms: healthy controls 1594 ± 220ms vs PD 1576 ± 155ms, PPs 1594 ± 220ms, AMS 1639 ± 166ms (p<0.001). SSR amplitude in soles: healthy 747uV (432-1755uV) vs Parkinson 241uV (179-388uV) (p=0.005).
Conclusions: The autonomic nervous system evaluation gives us vital information of the cardiac innervation. The significant difference found in these patients shows severe heart denervation both sympathetic and parasympathetic. We suggest these tests as part of the evaluation in patients with PD, MSA and PPs.
Poster. XXXVIII Annual meeting of the Mexican Academy of Neurology. Cancun, Mexico. November 1-7 2014.
To cite this abstract in AMA style:
R.C. Callejas Rojas, B. Estañol Vidal. Heart rate variability and sympathetic skin response are useful in the evaluation of Parkinson’s disease, AMS, and Parkinson plus syndrome, but underutilized in daily clinical practice [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/heart-rate-variability-and-sympathetic-skin-response-are-useful-in-the-evaluation-of-parkinsons-disease-ams-and-parkinson-plus-syndrome-but-underutilized-in-daily-clinical-practice/. Accessed June 14, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/heart-rate-variability-and-sympathetic-skin-response-are-useful-in-the-evaluation-of-parkinsons-disease-ams-and-parkinson-plus-syndrome-but-underutilized-in-daily-clinical-practice/